Results 31 to 40 of about 59,136 (254)

Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)

Frontiers in Cell and Developmental Biology, 2021
Identification and approval of new drugs for use in patients requires extensive preclinical studies and clinical trials. Preclinical studies rely on in vitro experiments and animal models of human diseases.
Mridu Malik, Mridu Malik, Yang Yang, Yang Yang, Parinaz Fathi, Gretchen J. Mahler, Mandy B. Esch   +6 more
doaj   +1 more source

Recapitulating Solid Stress on Tumor on a Chip for Nanomedicine Diffusive Transport Prediction

Advanced NanoBiomed Research, 2023
The characteristic mechanical forces at play within tumors include the abnormal solid and fluid stresses. These, together with the increased extracellular matrix (ECM) stiffness, are the major transport barriers affecting the nanomedicine delivery to ...
Alberto Martín-Asensio, Sergio Dávila, Jean Cacheux, Agnieszka Lindstaedt, Alicja Dziadosz, Darius Witt, Macarena Calero, Igor Balaz, Isabel Rodríguez   +8 more
doaj   +1 more source

Organ on a Chip

Colloids and Surfaces B: Biointerfaces
Traditional drug development methods have relied on 2D cell cultures and animal models, which have not been able to adequately represent human biology. Due to genetic and physiological variances in human biology, animal models cannot yield accurate results, whereas 2D cell cultures are insufficient in simulating tissue architecture and cell-to-cell ...
Aarif Ali, Ishteyaq Majeed Shah, Mohammad Saleem Bhat, Zainab Manzoor, Aadil Ayaz, Muneeb U. Rehman, Sheikh Bilal Ahmad   +6 more
  +4 more sources

Hemostasis-On-a-Chip: Impedance Spectroscopy Meets Microfluidics for Hemostasis Evaluation

Micromachines, 2019
In the case of vascular injury, a complex process (of clotting) starts, involving mainly platelets and coagulation factors. This process in healthy humans is known as hemostasis, but when it is deregulated (thrombosis), it can be the cause of important ...
Shadi Karimi, Josep Farré-Lladós, Enrique Mir, Ginés Escolar, Jasmina Casals-Terré   +4 more
doaj   +1 more source

Towards establishing human body-on-a-chip systems

Stem Cell Research & Therapy, 2022
Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically ...
Zhong Alan Li, Rocky S. Tuan
doaj   +1 more source

Lung on a Chip Development from Off-Stoichiometry Thiol–Ene Polymer

Micromachines, 2021
Current in vitro models have significant limitations for new respiratory disease research and rapid drug repurposing. Lung on a chip (LOAC) technology offers a potential solution to these problems.
Roberts Rimsa, Artis Galvanovskis, Janis Plume, Felikss Rumnieks, Karlis Grindulis, Gunita Paidere, Sintija Erentraute, Gatis Mozolevskis, Arturs Abols   +8 more
doaj   +1 more source

Sociodemographic Factors Associated With Later Stage at Diagnosis of Pediatric Germ Cell Tumors: A Report From Children's Oncology Group Registries ACCRN07 and APEC14B1

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Germ cell tumors (GCTs) often arise in the ovaries and testes (extracranial) but can also develop in the brain (intracranial). We examined the relationship of individual, family, and community‐level socioeconomic status (SES) with stage of disease at diagnosis in a cohort of pediatric patients with GCT from Children's Oncology Group
Heydon K. Kaddas, Judy Y. Ou, Todd Alonzo, Logan G. Spector, Negar Fallahazad, Emily Owens, Anne C. Kirchhoff, Adam L. Green   +7 more
wiley   +1 more source

PLGA Nanofiber/PDMS Microporous Composite Membrane-Sandwiched Microchip for Drug Testing

Micromachines, 2020
Lung-on-a-chip devices could provide new strategies for a biomimetic lung cell microenvironment and construction of lung disease models in vitro, and are expected to greatly promote the development of drug evaluation, toxicological detection, and disease
Wei Li, Xindi Sun, Bing Ji, Xingyuan Yang, Bingpu Zhou, Zhanjun Lu, Xinghua Gao   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source