Results 31 to 40 of about 91,588,802 (303)
Aggregate, 2023 Organ‐on‐a‐chip (OOC) platforms recapitulate human in vivo‐like conditions more realistically compared to many animal models and conventional two‐dimensional cell cultures.
Sajjad Rahmani Dabbagh +5 more
doaj +1 more source
Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing
Micromachines, 2021 Tissue chips (TCs) and microphysiological systems (MPSs) that incorporate human cells are novel platforms to model disease and screen drugs and provide an alternative to traditional animal studies.
Leslie Donoghue +3 more
doaj +1 more source
Toxicology Research and Application, 2017 In the last few years, considerable attention has been given to in vitro models in an attempt to reduce the use of animals and to decrease the rate of preclinical failure associated with the development of new drugs. Simple two-dimensional cultures grown in a dish are now frequently replaced by organotypic cultures with three-dimensional (3-D ...
David Bovard +4 more
openaire +1 more source
Design and engineering of organ-on-a-chip
Biomedical Engineering Letters, 2023 Organ-on-a-chip (OOC) is an emerging interdisciplinary technology that reconstitutes the structure, function, and physiology of human tissues as an alternative to conventional preclinical models for drug screening. Over the last decade, substantial progress has been made in mimicking tissue- and organ-level functions on chips through technical advances
Sujin Cho, Sumi Lee, Song Ih Ahn
openaire +2 more sources
Microfluidic Liver-on-a-Chip for Preclinical Drug Discovery
Pharmaceutics, 2023 Drug discovery is an expensive, long, and complex process, usually with a high degree of uncertainty. In order to improve the efficiency of drug development, effective methods are demanded to screen lead molecules and eliminate toxic compounds in the ...
Jingyu Fu, Hailong Qiu, Cherie S. Tan
doaj +1 more source
Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity
Bioactive Materials, 2021 Despite showing a great promise in the field of nanomedicine, nanoparticles have gained a significant attention from regulatory agencies regarding their possible adverse health effects upon environmental exposure.
Rick Xing Ze Lu, Milica Radisic
doaj +1 more source
Engineering human islet organoids from iPSCs using an organ-on-chip platform [PDF]
, 2019 Human pluripotent stem cell (hPSC)-derived islet cells provide promising resources for diabetes studies, cell replacement treatment and drug screening.
Li, Zhongyu +7 more
core +1 more source
The tooth on-a-chip: a microphysiologic model system mimicking the biologic interface of the tooth with biomaterials [PDF]
, 2020 The tooth has a unique configuration with respect to biomaterials that are used for its treatment. Cells inside of the dental pulp interface indirectly with biomaterials via a calcified permeable membrane, formed by the dentin matrix and several ...
Bertassoni, Luiz E. +7 more
core +1 more source
Microfluidic-Chip-Integrated Biosensors for Lung Disease Models
Biosensors, 2021 Lung diseases (e.g., infection, asthma, cancer, and pulmonary fibrosis) represent serious threats to human health all over the world. Conventional two-dimensional (2D) cell models and animal models cannot mimic the human-specific properties of the lungs.
Shuang Ding, Haijun Zhang, Xuemei Wang
doaj +1 more source
Organ-on-a-chip technology for nanoparticle research [PDF]
Nano Convergence, 2021 AbstractThe last two decades have witnessed explosive growth in the field of nanoengineering and nanomedicine. In particular, engineered nanoparticles have garnered great attention due to their potential to enable new capabilities such as controlled and targeted drug delivery for treatment of various diseases.
Shawn Kang +2 more
openaire +3 more sources