Results 31 to 40 of about 127,842,725 (298)

Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity

Bioactive Materials, 2021
Despite showing a great promise in the field of nanomedicine, nanoparticles have gained a significant attention from regulatory agencies regarding their possible adverse health effects upon environmental exposure.
Rick Xing Ze Lu, Milica Radisic
doaj   +1 more source

3D Inkjet-Bioprinted Lung-on-a-Chip

, 2023
There is an urgent need for physiologically relevant and customizable biochip models of human lung tissue to provide a niche for lung disease modeling and drug efficacy.
Dayoon Kang, Taejeong Kwak (15334091), Hwa-Rim Lee, Wookyeom Kim (15334082), Sungjune Jung (3236640), Wookyeom Kim, Yunji Lee, Hwa-Rim Lee (9072215), Taejeong Kwak, Sungjune Jung, Yunji Lee (15334085), Dayoon Kang (15334088)   +11 more
core   +1 more source

Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)

Frontiers in Cell and Developmental Biology, 2021
Identification and approval of new drugs for use in patients requires extensive preclinical studies and clinical trials. Preclinical studies rely on in vitro experiments and animal models of human diseases.
Mridu Malik, Mridu Malik, Yang Yang, Yang Yang, Parinaz Fathi, Gretchen J. Mahler, Mandy B. Esch   +6 more
doaj   +1 more source

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

, 2022
S.2688-2699Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic candidates. However, these systemic responses of applied
Drewell, Christopher, Sambo, Naomia Sisoli, Thomas, Alexander, Lauster, Roland, Lorenz, Alexandra K., Lindner, Marcus, Maschmeyer, Ilka, Ramme, Anja P., Bauer, Sophie, Marx, Uwe, Schimek, Katharina, Hübner, Juliane, Hasenberg, Tobias, Sonntag, Frank   +13 more
core   +1 more source

WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue

, 2022
S.1645-1654Organ-on-a-chip systems possess a promising future as drug screening assays and as testbeds for disease modeling in the context of both single-organ systems and multi-organ-chips.
Zushin, P.J.H., Healy, K.E., Stahl, A., Reese, W.M., Loskill, P., Lee-Montiel, F.T., Jeeawoody, S., Sezhian, T., Tharp, K.M.   +8 more
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Cystic Fibrosis Human Organs-on-a-Chip [PDF]

Micromachines, 2021
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene: the gene product responsible for transporting chloride and bicarbonate ions through the apical membrane of most epithelial cells.
Herbert Luke Ogden, Hoyeol Kim, Kathryn A. Wikenheiser-Brokamp, Anjaparavanda P. Naren, Kyu Shik Mun   +4 more
openaire   +3 more sources

Recapitulating Solid Stress on Tumor on a Chip for Nanomedicine Diffusive Transport Prediction

Advanced NanoBiomed Research, 2023
The characteristic mechanical forces at play within tumors include the abnormal solid and fluid stresses. These, together with the increased extracellular matrix (ECM) stiffness, are the major transport barriers affecting the nanomedicine delivery to ...
Alberto Martín-Asensio, Sergio Dávila, Jean Cacheux, Agnieszka Lindstaedt, Alicja Dziadosz, Darius Witt, Macarena Calero, Igor Balaz, Isabel Rodríguez   +8 more
doaj   +1 more source

High-resolution and multi-range particle separation by microscopic vibration in an optofluidic chip

, 2017
An optofluidic chip is demonstrated in experiments for high-resolution and multi-range particle separation through the optically-induced microscopic vibration effect, where nanoparticles are trapped in loosely overdamped optical potential wells created ...
Zhang, Jing Bo, Liedberg, B., Liedberg, Bo, P. H. Yap, Y. Zhang, Yap, P. H., Zhang, Yi, Xiong, S., Zhang, Y., Chen, T. N., Y. L. Hao, Chin, Lip Ket, Chin, L. K., S. Xiong, Shi, Yu Zhi, Ser, Wee, Y. Yang, W. Ser, Liu, A. Q., J. B. Zhang, Xiong, Sha, Hao, Yi Long, J. H. Wu, Hao, Y. L., Chen, Tian Ning, A. Q. Liu, Y. Z. Shi, Wu, Jiu Hui, Zhang, J. B., B. Liedberg, Yang, Z. C., Yang, Y., Wu, J. H., Ser, W., Yang, Zhen Chuan, Yap, Peng Huat, Shi, Y. Z., Liu, Ai Qun, T. N. Chen, Z. C. Yang, L. K. Chin, Yang, Yi   +41 more
core   +1 more source

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

, 2022
S.3538-3547Current in vitro and animal tests for drug development are failing to emulate the systemic organ complexity of the human body and, therefore, to accurately predict drug toxicity.
Lauster, R., Tonevitsky, A.G., Sakharov, D.A., Süßbier, U., Trushkin, E.V., Sonntag, F., Frädrich, C., Brincker, S., Busek, M., Wagner, I., Marx, U., Materne, E.-M.   +11 more
core   +1 more source

Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications

, 2019
Organ-on-chips are miniaturised devices aiming at replacing animal models for drug discovery, toxicology and studies of complex biological phenomena. The field of Organ-On-Chip has grown exponentially, and has led to the formation of companies providing ...
Arianna Mencatti, Alfredo E. Ongaro, Lina Ghibelli, Vanessa Mancini, Vicki Stone, Maïwenn Kersaudy-Kerhoas, MaÃwenn Kersaudy-Kerhoas, Virginia Pensabene, Allende Miguelez Crespo, Krystian L. Wlodarczyk, Duncan P. Hand, Nicola Howarth, Davide Di Giuseppe, Vincenzo La Carrubba, Ali Kermanizadeh, Eugenio Martinelli   +15 more
core   +1 more source