Results 11 to 20 of about 91,588,802 (303)
Fabrication of organ-on-a-chip using microfluidics [PDF]
BioprintingThe use of microfluidic devices represents a significant advancement beyond conventional techniques in the development of innovative in vitro assays. Microfluidic chips are specialized devices that precisely control fluids at the microscale level through intricate microchannels, enabling the replication of physical and chemical conditions.
S. Ying-Jin +3 more
openaire +3 more sources
Integrating biological vasculature into a multi-organ-chip microsystem [PDF]
, 2022 S.3588-3598A chip-based system mimicking the transport function of the human cardiovascular system has been established at minute but standardized microsystem scale.
Lindner, G. +12 more
core +1 more source
Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems [PDF]
, 2022 S.3963-3978Organ-on-chip (OoC) systems have become a promising tool for personalized medicine and drug development with advantages over conventional animal models and cell assays.
Rogal, Julia +8 more
core +1 more source
Open Research Europe, 2023 It is difficult to model in vitro the intestine when seeking to include crosstalk with the gut microbiota, immune and neuroendocrine systems. Here we present a roadmap of the current models to facilitate the choice in preclinical and translational ...
Giulia Malaguarnera +2 more
doaj +1 more source
Three-Dimensional-Bioprinted Liver Chips and Challenges
Applied Sciences, 2022 Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries ...
Sajjad Rahmani Dabbagh +3 more
doaj +1 more source
Membrane integration into PDMS-free microfluidic platforms for organ-on-chip and analytical chemistry applications [PDF]
, 2022 S.1866-1885Membranes play a crucial role in many microfluidic systems, enabling versatile applications in highly diverse research fields. However, the tight and robust integration of membranes into microfluidic systems requires complex fabrication ...
Schneider, S. +3 more
core +1 more source
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2022 Microfluidic chip systems have been an area of interest for lab-on-a-chip and organ-on-a-chip studies in recent years. These chips have many advantages such as high efficiency, low sample consumption, fast analysis, durability and low cost.
Fatma Doğan Guzel +2 more
doaj +1 more source
Recent advances in vascularized tumor-on-a-chip
Frontiers in Oncology, 2023 The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust tool, capable of ...
Christina Bao Xian Huang +3 more
doaj +1 more source
Experimental Cell Research, 2018 The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases. In contrast to other solid organs, the liver possesses the unique ability to regenerate. The physiological importance and plasticity
Beckwitt, Colin H. +6 more
openaire +4 more sources
Microfluidic Gut-on-a-Chip: Fundamentals and Challenges
Biosensors, 2023 The human gut is responsible for food digestion and absorption. Recently, growing evidence has shown its vital role in the proper functioning of other organs.
Dimple Palanilkunnathil Thomas +3 more
doaj +1 more source