Results 11 to 20 of about 62,519 (299)
Experimental Cell Research, 2018 The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases. In contrast to other solid organs, the liver possesses the unique ability to regenerate. The physiological importance and plasticity
Beckwitt, Colin H. +6 more
openaire +7 more sources
Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering [PDF]
Sensors, 2015 Recent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate ...
Ana Rubina Perestrelo +3 more
doaj +4 more sources
Three-Dimensional-Bioprinted Liver Chips and Challenges
Applied Sciences, 2022 Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries ...
Sajjad Rahmani Dabbagh +3 more
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Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2022 Microfluidic chip systems have been an area of interest for lab-on-a-chip and organ-on-a-chip studies in recent years. These chips have many advantages such as high efficiency, low sample consumption, fast analysis, durability and low cost.
Fatma Doğan Guzel +2 more
doaj +1 more source
Recent advances in vascularized tumor-on-a-chip
Frontiers in Oncology, 2023 The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust tool, capable of ...
Christina Bao Xian Huang +3 more
doaj +1 more source
Microfluidic Gut-on-a-Chip: Fundamentals and Challenges
Biosensors, 2023 The human gut is responsible for food digestion and absorption. Recently, growing evidence has shown its vital role in the proper functioning of other organs.
Dimple Palanilkunnathil Thomas +3 more
doaj +1 more source
Multi-scale cellular engineering: From molecules to organ-on-a-chip. [PDF]
, 2020 Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems.
Cahan, Patrick +8 more
core +2 more sources
Cystic Fibrosis Human Organs-on-a-Chip [PDF]
Micromachines, 2021 Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene: the gene product responsible for transporting chloride and bicarbonate ions through the apical membrane of most epithelial cells.
Herbert Luke Ogden +4 more
openaire +3 more sources
Modeling human trophoblast, the placental epithelium at the maternal fetal interface. [PDF]
, 2020 Appropriate human trophoblast lineage specification and differentiation is crucial for the establishment of normal placentation and maintenance of pregnancy. However, due to the lack of proper modeling systems, the molecular mechanisms of these processes
Bui, Tony +3 more
core +1 more source
Acoustic Characterization of a Vessel-on-a-Chip Microfluidic System for Ultrasound-Mediated Drug Delivery [PDF]
, 2018 Ultrasound in the presence of gas-filled microbubbles can be used to enhance local uptake of drugs and genes. To study the drug delivery potential and its underlying physical and biological mechanisms, an in vitro vessel model should ideally include 3D ...
Beekers, I. (Inés) +6 more
core +14 more sources