Results 101 to 110 of about 3,139,625 (302)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Multi-label classification using ensembles of pruned sets
, 2008 This paper presents a Pruned Sets method (PS) for multi-label classification. It is centred on the concept of treating sets of labels as single labels. This allows the classification process to inherently take into account correlations between labels. By
Pfahringer, Bernhard +5 more
core +1 more source
NOVEL FREE LABEL BOTULINUM APTASENSOR BASED ON CAPACITANCE METHOD
Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2016 A feasible and fast method to fabricate Botulinum neurotoxin serotype A (BoNT/A) biosensor was investigated by graphene-carbon paste nanocomposite electrode. In the present work, the graphene was synthesis by chemical method and characterized by SEM. The
JAMAL RASHIDIANI +3 more
doaj
Label-Free Quantitation for Clinical Proteomics
, 2016 Label-free quantification (LFQ) has emerged as a viable option for quantitative LC-MS/MS-based proteomic analyses for use on the scale of hundreds of samples such as are encountered in clinical analysis. Notably, sample preparation, sample loading, HPLC separations, and mass spectrometric performance must be highly reproducible for this approach to be ...
Robert Moulder +2 more
openaire +3 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Label-free biochemical quantitative phase imaging with mid-infrared photothermal effect
, 2019 Label-free optical imaging is valuable in biology and medicine with its non-destructive property and reduced optical and chemical damages. Quantitative phase (QPI) and molecular vibrational imaging (MVI) are the two most successful label-free methods ...
Keiichiro Toda (8623476) +8 more
core +1 more source
Label-free volumetric histopathology of thick-tissue slides - PanIN, low grade
, 2020 Label-free volumetric histopathology of thick-tissue slides - PanIN, low ...
yongkeun park (8695308)
core +1 more source
Label-free and label-based electrochemical detection of disease biomarker proteins
ADMET and DMPKIntroduction: Biosensors, analytical devices integrating biological sensing elements with physicochemical transducers, have gained prominence as rapid and convenient tools for monitoring human health status using biochemical analytes.
Tias Febriana Hanifa Lestari +7 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Label-free multiphoton microscopy: Much more than fancy images
, 2021 © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Multiphoton microscopy has recently passed the milestone of its first 30 years of activity in biomedical research.
D Sandrin (10576958) +4 more
core