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2021
In this chapter, we focus on label-free biosensors. First, we look at sensors with optical detection. In this context, the Mach–Zehnder interferometer and the surface plasmon resonance offer the possibility to limit the optical examination to shallow surface layers. The second group are the gravimetric biosensors.
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In this chapter, we focus on label-free biosensors. First, we look at sensors with optical detection. In this context, the Mach–Zehnder interferometer and the surface plasmon resonance offer the possibility to limit the optical examination to shallow surface layers. The second group are the gravimetric biosensors.
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Label-Free Microelectronic PCR Quantification
Analytical Chemistry, 2006We present a robust and simple method for direct, label-free PCR product quantification using an integrated microelectronic sensor. The field-effect sensor can sequentially detect the intrinsic charge of multiple unprocessed PCR products and does not require sample processing or additional reagents in the PCR mixture.
Chih-Sheng Johnson, Hou +5 more
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Label-free biodetection using a smartphone
Lab on a Chip, 2013Utilizing its integrated camera as a spectrometer, we demonstrate the use of a smartphone as the detection instrument for a label-free photonic crystal biosensor. A custom-designed cradle holds the smartphone in fixed alignment with optical components, allowing for accurate and repeatable measurements of shifts in the resonant wavelength of the sensor.
Dustin, Gallegos +7 more
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Label-free capacitance DNA sensing
2013 Seventh International Conference on Sensing Technology (ICST), 2013This paper presents the use of direct capacitance measurements for label free hybridization detection of ssDNA immobilized directly on a gold interdigitated array of microelectrodes (IDAM). Thiol modified 18 bases long Poly-dT ssDNA molecules were immobilized on the Au IDAM surface without the use of any isolative self assembled monolayer (SAM ...
Phillip M. Rivera Ortiz +3 more
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Label-Free Quantitative Phosphoproteomics for Algae
2020The unicellular alga Chlamydomonas reinhardtii is a model photosynthetic organism for the study of microalgal processes. Along with genomic and transcriptomic studies, proteomic analysis of Chlamydomonas has led to an increased understanding of its metabolic signaling as well as a growing interest in the elucidation of its phosphorylation networks.
Megan M, Ford +4 more
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Nature Methods, 2009
New methods to coax signals from unlabeled biological molecules may finally fulfill the promise of practical label-free microscopy with molecular specificity.
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New methods to coax signals from unlabeled biological molecules may finally fulfill the promise of practical label-free microscopy with molecular specificity.
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Label-Free Functional Selectivity Assays
2015G protein-coupled receptors (GPCRs) represent the largest class of drug targets. Ligand-directed functional selectivity or biased agonism opens new possibility for discovering GPCR drugs with better efficacy and safety profiles. However, quantification of ligand bias is challenging.
Ann M, Ferrie +3 more
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Virtual Staining of Label-free Tissue
Frontiers in Optics + Laser Science 2024 (FiO, LS)We will cover deep learning-based virtual staining techniques that can generate different types of histological stains from label-free microscopic images of unstained samples by using, e.g., autofluorescence microscopy, quantitative phase imaging and reflectance confocal microscopy.
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Label-free biological and chemical sensors
Nanoscale, 2010Highly sensitive, label-free biodetection methods have applications in both the fundamental research and healthcare diagnostics arenas. Therefore, the development of new transduction methods and the improvement of the existing methods will significantly impact these areas.
Heather K, Hunt, Andrea M, Armani
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Spectral Counting Label-Free Proteomics
2014Label-free proteome quantification methods used in bottom-up mass-spectrometry based proteomics are gaining more popularity as they are easy to apply and can be integrated into different workflows without any extra effort or cost. In the label-free proteome quantification approach, samples of interest are prepared and analyzed separately.
Liisa, Arike, Lauri, Peil
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