Results 1 to 10 of about 440,228 (95)

Label‐Free Single‐Molecule Immunoassay [PDF]

Advanced Science
Single‐molecule immunoassay is a reliable technique for the detection and quantification of low‐abundance blood biomarkers, which are essential for early disease diagnosis and biomedical research.
Xiaoyan Zhou, Chao Chen, Shuang Zhou, Guangzhong Ma, Mohammad Javad H. N. Chemerkouh, Christine L. H. Snozek, Eric H. Yang, Jiapei Jiang, Brandyn Braswell, Zijian Wan, Xinyu Zhou, Shaopeng Wang   +11 more
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Label-Free Single-Molecule Conalbumin Analysis [PDF]

Micromachines
Nanoaperture optical tweezers (NOTs) were used to analyze conalbumin in various forms. By analyzing the power spectrum of the NOT-transmitted laser signal, differences between iron and iron-free conalbumin were observed; the corner frequency extrapolated
Tianyu Zhao, Xi Ren, Reuven Gordon
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Label‐Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes [PDF]

Advanced Science
Astrocyte cell differentiation to their characteristic starlike morphology with the expression of proteins in microdomains, critical for normal brain function, occurs naturally in‐vivo but can be affected in pathological condition or in cell culture in ...
Panagis D. Samolis, Chiara Lazzarini, Rahmetullah Durgun, Barbara Barile, Giorgia Conte, Tamara Posati, Marco Caprini, Grazia Paola Nicchia, Valentina Benfenati, Michelle Y. Sander   +9 more
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Label‐Free and Immobilization‐Free Protein‐Binding Assays by Ultraviolet Transient Absorption Microscopy [PDF]

Advanced Science
Protein–ligand interactions are central to understanding biological mechanisms and drug discovery, yet conventional assays often rely on labeling or immobilization that can alter natural binding.
Jianghao Shen, Qiangqiang Wang, Fan Wu, Yang Gao, Lu Lan, Pu Wang   +5 more
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A review on label free biosensors

Biosensors and Bioelectronics: X, 2022
Label-free biosensing has advanced significantly in recent years due to its capacity for quick and inexpensive bio-detection in small volumes. Additionally, they have developed into lab-on-a-chip technology and may be able to perform real-time analysis ...
Vimala Rani Samuel, K.Jagajjanani Rao
doaj   +1 more source

Zero‐shot temporal event localisation: Label‐free, training‐free, domain‐free

IET Computer Vision, 2023
Temporal event localisation (TEL) has recently attracted increasing attention due to the rapid development of video platforms. Existing methods are based on either fully/weakly supervised or unsupervised learning, and thus they rely on expensive data ...
Li Sun, Ping Wang, Liuan Wang, Jun Sun, Takayuki Okatani   +4 more
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Multi‐parametric surface plasmon resonance‐based intake quantification of label‐free light‐activated nanoparticles by therapeutic limbal stem cells for corneal blindness

Nano Select, 2022
Advanced therapies with combined approaches of cell and nanomedicine‐based interventions are emerging. Corneal blindness with a severe form of limbal stem cell (LSC) deficiency is an example of defect with unmet clinical need. Towards cell‐based therapy,
Maija Kauppila, Roosa Ståhlberg, Vitor Francisco, Lino Ferreira, Heli Skottman   +4 more
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High‐Refractive‐Index Chip with Periodically Fine‐Tuning Gratings for Tunable Virtual‐Wavevector Spatial Frequency Shift Universal Super‐Resolution Imaging

Advanced Science, 2022
Continued research in fields such as materials science and biomedicine requires the development of a super‐resolution imaging technique with a large field of view (FOV) and deep subwavelength resolution that is compatible with both fluorescent and ...
Mingwei Tang, Yubing Han, Dehao Ye, Qianwei Zhang, Chenlei Pang, Xiaowei Liu, Weidong Shen, Yaoguang Ma, Clemens F. Kaminski, Xu Liu, Qing Yang   +10 more
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Label-Free Biosensor

Biosensors, 2023
Label-free biosensors have become an indispensable tool for analyzing intrinsic molecular properties, such as mass, and quantifying molecular interactions without interference from labels, which is critical for the screening of drugs, detecting disease ...
Pengfei Zhang, Rui Wang
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Estimation of the proteome affecting changes in tenderness of yak meat during storage by label‐free mass spectrometry

Veterinary Medicine and Science, 2022
Background Tenderness is the main quality of meat products. However, the meat tenderness formation is a complex biological process, and pathways and proteins that affect the tenderness of yak meat are unknown.
Shengsheng Li, Shujie Liu
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