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Label-Free Sensing on Microarrays
2016Microarrays of biological molecules such as DNAs, proteins, carbohydrates, and small molecules provide a high-throughput platform for screening tens of thousands of biomolecular interactions simultaneously, facilitating the functional characterization of these biomolecules in areas of genomics, proteomics, glycomics, and cytomics.
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Nature Methods, 2009
New methods to coax signals from unlabeled biological molecules may finally fulfill the promise of practical label-free microscopy with molecular specificity.
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New methods to coax signals from unlabeled biological molecules may finally fulfill the promise of practical label-free microscopy with molecular specificity.
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Label-free biodetection using a smartphone
Lab on a Chip, 2013Utilizing its integrated camera as a spectrometer, we demonstrate the use of a smartphone as the detection instrument for a label-free photonic crystal biosensor. A custom-designed cradle holds the smartphone in fixed alignment with optical components, allowing for accurate and repeatable measurements of shifts in the resonant wavelength of the sensor.
Dustin, Gallegos +7 more
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Label-free capacitance DNA sensing
2013 Seventh International Conference on Sensing Technology (ICST), 2013This paper presents the use of direct capacitance measurements for label free hybridization detection of ssDNA immobilized directly on a gold interdigitated array of microelectrodes (IDAM). Thiol modified 18 bases long Poly-dT ssDNA molecules were immobilized on the Au IDAM surface without the use of any isolative self assembled monolayer (SAM ...
Phillip M. Rivera Ortiz +3 more
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Virtual Staining of Label-free Tissue
Frontiers in Optics + Laser Science 2024 (FiO, LS)We will cover deep learning-based virtual staining techniques that can generate different types of histological stains from label-free microscopic images of unstained samples by using, e.g., autofluorescence microscopy, quantitative phase imaging and reflectance confocal microscopy.
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Label-Free Quantitative Phosphoproteomics for Algae
2020The unicellular alga Chlamydomonas reinhardtii is a model photosynthetic organism for the study of microalgal processes. Along with genomic and transcriptomic studies, proteomic analysis of Chlamydomonas has led to an increased understanding of its metabolic signaling as well as a growing interest in the elucidation of its phosphorylation networks.
Megan M, Ford +4 more
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Label-Free Functional Selectivity Assays
2015G protein-coupled receptors (GPCRs) represent the largest class of drug targets. Ligand-directed functional selectivity or biased agonism opens new possibility for discovering GPCR drugs with better efficacy and safety profiles. However, quantification of ligand bias is challenging.
Ann M, Ferrie +3 more
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Label‐Free Technologies for Drug Discovery
2011Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their ...
Cooper, Matthew, Mayr, Lorenz M.
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Functional blood cell analysis by label-free biosensors and single-cell technologies
Advances in Colloid and Interface Science, 2022Beatrix Peter +2 more
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