Results 91 to 100 of about 4,376,632 (304)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Label-Free Single-Molecule Conalbumin Analysis

Micromachines
Nanoaperture optical tweezers (NOTs) were used to analyze conalbumin in various forms. By analyzing the power spectrum of the NOT-transmitted laser signal, differences between iron and iron-free conalbumin were observed; the corner frequency extrapolated
Tianyu Zhao, Xi Ren, Reuven Gordon
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Label Free Detection of L-Glutamate Using Microfluidic Based Thermal Biosensor

Bioengineering, 2015
A thermoelectric biosensor for the detection of L-glutamate concentration was developed. The thermoelectric sensor is integrated into a micro-calorimeter which measures the heat produced by biochemical reactions.
Varun Lingaiah Kopparthy, Siva Mahesh Tangutooru, Eric J. Guilbeau   +2 more
doaj   +1 more source

Label-free image scanning microscopy for kHz super-resolution imaging and single particle tracking

, 2023
We report the modification of a label-free image scanning microscope (ISM) to perform asynchronous 2D imaging at 24kHz while keeping the lateral resolution gain and background rejection of a regular label-free ISM setup. Our method uses a resonant mirror
Alberto Aguilar (16896558), Duc-Minh Ta (16896552), Pierre Bon (2099782)   +2 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

NOVEL FREE LABEL BOTULINUM APTASENSOR BASED ON CAPACITANCE METHOD

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2016
A feasible and fast method to fabricate Botulinum neurotoxin serotype A (BoNT/A) biosensor was investigated by graphene-carbon paste nanocomposite electrode. In the present work, the graphene was synthesis by chemical method and characterized by SEM. The
JAMAL RASHIDIANI, SAYED JAEFAR MOOSAVI, KHADIJEH ESKANDARI, FIROOZ EBRAHIMI   +3 more
doaj  

Bacteria Detection: From Powerful SERS to Its Advanced Compatible Techniques

Advanced Science, 2020
The rapid, highly sensitive, and accurate detection of bacteria is the focus of various fields, especially food safety and public health. Surface‐enhanced Raman spectroscopy (SERS), with the advantages of being fast, sensitive, and nondestructive, can be
Xia Zhou, Ziwei Hu, Danting Yang, Shouxia Xie, Zhengjin Jiang, Reinhard Niessner, Christoph Haisch, Haibo Zhou, Pinghua Sun   +8 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Label-free and label-based electrochemical detection of disease biomarker proteins

ADMET and DMPK
Introduction: Biosensors, analytical devices integrating biological sensing elements with physicochemical transducers, have gained prominence as rapid and convenient tools for monitoring human health status using biochemical analytes.
Tias Febriana Hanifa Lestari, Irkham Irkham, Uji Pratomo, Shabarni Gaffar, Salma Nur Zakiyyah, Isnaini Rahmawati, Seda Nur Topkaya, Yeni Wahyuni Hartati   +7 more
doaj   +1 more source