Results 121 to 130 of about 4,376,632 (304)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Information‐Distilled Generative Label‐Free Morphological Profiling Encodes Cellular Heterogeneity

open access: yesAdvanced Science
Image‐based cytometry faces challenges due to technical variations arising from different experimental batches and conditions, such as differences in instrument configurations or image acquisition protocols, impeding genuine biological interpretation of ...
Michelle C. K. Lo   +7 more
doaj   +1 more source

Label-free imaging of fibroblast membrane interfaces and protein signatures with vibrational infrared photothermal and phase signals

open access: yes, 2021
Label-free vibrational imaging of biological samples has attracted significant interest due to its integration of structural and chemical information.
AE Sgro (18929410)   +8 more
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

Label-Free and Real-Time Optical Detection of Affinity Binding of the Antibody on Adherent Live Cells

open access: yes
Oblique-incidence reflectivity difference (OIRD) is a novel real-time, label-free, and nondestructive optical detection method and exhibits encouraging application in the detection of antibody/DNA microarrays.
Xiaoyi Li (669720)   +6 more
core   +1 more source

An Informatics-Assisted Label-Free Quantitation Strategy That Depicts Phosphoproteomic Profiles in Lung Cancer Cell Invasion

open access: yes, 2011
Aberrant protein phosphorylation plays important roles in cancer-related cell signaling. With the goal of achieving multiplexed, comprehensive, and fully automated relative quantitation of site-specific phosphorylation, we present a simple label-free ...
王薏婷;鄒志强;林佩儀;潘思樺;洪澤民;楊泮池;宋定懿;許聞廉;陳玉如   +1 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Label-free 3D molecular imaging of living tissues using Raman spectral projection tomography

open access: yesNature Communications
The ability to image tissues in three dimensions (3D) with label-free molecular contrast at the mesoscale would be a valuable capability in biology and biomedicine.
Elzbieta Stepula   +10 more
doaj   +1 more source

Consumer Behaviour towards Own Label: monitoring the Greek experience [PDF]

open access: yes
In Greece, the traditional perceptions of private label were once of low quality, unbranded alternatives, attracting the most cost-conscious consumers.
Boutsouki, Christina   +2 more
core  

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