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Label-free T cell characterization
Nature Methods, 2020A machine learning model uses autofluorescence of key metabolites to predict T cell activation state.
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Multimodal label-free microscopy
2013 Conference on Lasers and Electro-Optics Pacific Rim (CLEOPR), 2013We developed a multimodal microscope enabling simultaneous measurement of two label-free imaging methods, Raman microscopy and quantitative phase imaging. This approach provides real-time measurements through phase microscopy, along with the chemical specificity of Raman spectroscopy.
N. Pavillon, N. I. Smith
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Label-free hyperspectral multiphoton microscopy
Optics LettersLabel-free multiphoton microscopy is a powerful tool for investigating pristine biological specimens. This imaging modality leverages optical signals originating from the nonlinear response of native biomolecules to intense optical radiation, nonlinear signals that allow localizing and quantifying the constituents of specimens, driving applications in ...
Alejandro De la Cadena +3 more
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Label-Free Sensing on Microarrays
2016Microarrays of biological molecules such as DNAs, proteins, carbohydrates, and small molecules provide a high-throughput platform for screening tens of thousands of biomolecular interactions simultaneously, facilitating the functional characterization of these biomolecules in areas of genomics, proteomics, glycomics, and cytomics.
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Electrochemical Label‐Free Nucleotide Sensors
Chemistry – An Asian Journal, 2015AbstractNumerous researchers have devoted a great deal of effort over the last few decades to the development of electrochemical oligonucleotide detection techniques, owing to their advantages of simple design, inherently small dimensions, and low power requirements. Their simplicity and rapidity of detection makes label‐free oligonucleotide sensors of
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2018
Label-free Raman imaging is a noninvasive spectroscopic method for investigating the nature and distribution of molecular species within a sample. In this chapter, we describe the applications of conventional Raman imaging, as well as the related techniques of coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS) imaging ...
Alison J. Hobro, Nicholas I. Smith
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Label-free Raman imaging is a noninvasive spectroscopic method for investigating the nature and distribution of molecular species within a sample. In this chapter, we describe the applications of conventional Raman imaging, as well as the related techniques of coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS) imaging ...
Alison J. Hobro, Nicholas I. Smith
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Virtual Staining of Label-free Tissue
Frontiers in Optics + Laser Science 2024 (FiO, LS)We will cover deep learning-based virtual staining techniques that can generate different types of histological stains from label-free microscopic images of unstained samples by using, e.g., autofluorescence microscopy, quantitative phase imaging and reflectance confocal microscopy.
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Free Energies of Proton-Coupled Electron Transfer Reagents and Their Applications
Chemical Reviews, 2022Rishi G Agarwal +2 more
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