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3D Super-resolution Label-free Imaging
Conference on Lasers and Electro-Optics, 2016We present 3D images of grooves on a writable Blu-rayr disc. In the vertical direction the resolution is a few nanometers while the lateral resolution is a few tenths of nanometers.
Nolvi Anton Mikael +2 more
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Label-Free Interference Imaging of Intracellular Trafficking
Accounts of Chemical ResearchIntracellular cargo trafficking is a highly regulated process responsible for transporting vital cellular components to their designated destinations. This intricate journey has been a central focus of cellular biology for many years. Early investigations leaned heavily on biochemical and genetic approaches, offering valuable insight into molecular ...
Jin-Sung Park +3 more
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Photoluminescent polymer nanoparticles for label-free cellular imaging
Chemical Communications, 2010Novel polymer based photoluminescent nanoparticles were fabricated by ultra-sound induced emulsion polymerization and applied to bioimaging of human breast cancer SK-BR-3 cells after ethylenediamine treatment and conjugation with anti-ErbB2 antibody.
Kyung Jin, Lee +5 more
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Label-Free in Situ SERS Imaging of Biofilms
The Journal of Physical Chemistry B, 2010Surface-enhanced Raman scattering (SERS) is a promising technique for the chemical characterization of biological systems. It yields highly informative spectra, can be applied directly in aqueous environment, and has high sensitivity in comparison with normal Raman spectroscopy.
Natalia P, Ivleva +5 more
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Imaging label-free intracellular structures by localisation microscopy
Micron, 2011Localisation microscopy methods allow to realize a light optical resolution far beyond the Abbe-Rayleigh limit of about 200 nm laterally and 600 nm axially. So far, this progress was achieved using labelling with appropriate fluorochromes and fluorescent proteins.
Kaufmann, Rainer +3 more
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Label-free optical imaging for brain cancer assessment
Trends in CancerAdvances in label-free optical imaging offer a promising avenue for brain cancer assessment, providing high-resolution, real-time insights without the need for radiation or exogeneous agents. These cost-effective and intricately detailed techniques overcome the limitations inherent in magnetic resonance imaging (MRI), computed tomography (CT), and ...
Raksha Raghunathan +4 more
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Label-Free Detection with Surface Plasmon Resonance Imaging
2011Sensors based on surface plasmon resonance have demonstrated, over the last 2 decades, to be an effective method of studying biomolecular interactions without the need for labeling. Recently, it has been adapted to high-throughput use for imaging microarray binding in real time.
Christopher, Lausted +2 more
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Label-Free Optical Imaging of Nanoscale Single Entities
ACS SensorsThe advancement of optical microscopy technologies has achieved imaging of nanoscale objects, including nanomaterials, virions, organelles, and biological molecules, at the single entity level. Recently developed plasmonic and scattering based optical microscopy technologies have enabled label-free imaging of single entities with high spatial and ...
Xinyu Zhou, Andy Chieng, Shaopeng Wang
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Label-free quantitative imaging of conjunctival goblet cells
The Ocular SurfaceTo introduce and validate quantitative oblique back-illumination microscopy (qOBM) as a label-free, high-contrast imaging technique for visualizing conjunctival goblet cells (GCs) and assessing their functional changes.qOBM was developed in conjunction with moxifloxacin-based fluorescence microscopy (MBFM), which was used for validating GC imaging ...
Noseong Park +8 more
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Terahertz imaging for label-free protein detection
2009 34th International Conference on Infrared, Millimeter, and Terahertz Waves, 2009We demonstrate an imaging method combined a terahertz time-domain spectroscopy and an interference effect for label-free protein detection on a membrane filter. Biotin is linked to the membrane using poly ethylene glycol (PEG) or poly ethylene glycol methyl ether (MPEG) to prevent it from being washed off.
Y. Ogawa +4 more
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