Analytical Science Advances, 2020 Surface‐enhanced Raman spectroscopic (SERS) approaches are emerging for bacteria analysis whereby bacteria cells can be measured based on their biochemical composition (label‐free) or with the aid of a chemical label to enhance the SERS signal. Combining
Michael E. Hickey, Siyue Gao, Lili He
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Hyperspectral Imaging with Stimulated Raman Scattering by Chirped Femtosecond Lasers [PDF]
, 2013 Raman microscopy is a quantitative, label-free, and noninvasive optical imaging technique for studying inhomogeneous systems. However, the feebleness of Raman scattering significantly limits the use of Raman microscopy to low time resolutions and ...
Freudiger, Christian Wilhelm +4 more
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Remote-mode microsphere nano-imaging: new boundaries for optical microscopes
Opto-Electronic Advances, 2018 Optical microscope is one of the most popular characterization techniques for general purposes in many fields. It is distinguished from the vacuum or tip-based imaging techniques for its flexibility, low cost, and fast speed.
Chen Lianwei +3 more
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Label-Free Macroscopic Fluorescence Lifetime Imaging of Brain Tumors
Frontiers in Oncology, 2021 Advanced stage glioma is the most aggressive form of malignant brain tumors with a short survival time. Real-time pathology assisted, or image guided surgical procedures that eliminate tumors promise to improve the clinical outcome and prolong the lives ...
Maria Lukina +14 more
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Highly sensitive and label-free digital detection of whole cell E. coli with interferometric reflectance imaging [PDF]
, 2019 Bacterial infectious diseases are a major threat to human health. Timely and sensitive pathogenic bacteria detection is crucial in identifying the bacterial contaminations and preventing the spread of infectious diseases.
Bhuiya, Abdul Muyeed +8 more
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Label Free Fluorescence Lifetime FRET Imaging [PDF]
Biophysical Journal, 2013 Multiphoton microscopy with endogenous contrasts in biological tissues have primarily focused on detecting signals from the reduced nicotinamide adenine dinucleatide (NADH), its dinucleatide phosphate (NADPH), riboflavins, and tryptophan. All these fluorophores have emission in the wavelength range of 400-600 nm.
Jyothikumar, Vinod +2 more
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Label-Free Prediction of Cell Painting from Brightfield Images [PDF]
Scientific Reports, 2021 ABSTRACTCell Painting is a high-content image-based assay which can reveal rich cellular morphology and is applied in drug discovery to predict bioactivity, assess toxicity and understand diverse mechanisms of action of chemical and genetic perturbations.
Jan Cross-Zamirski +5 more
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Label-free detection of anticancer drug paclitaxel in living cells by confocal Raman microscopy [PDF]
, 2013 Confocal Raman microscopy, a non-invasive, label-free, and high spatial resolution imaging technique is employed to trace the anticancer drug paclitaxel in living Michigan Cancer Foundation-7 (MCF-7) cells. The Raman images were treated by K-mean cluster
A.-G. Vegh +9 more
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Label-Free Nanometer-Resolution Imaging of Biological Architectures through Surface Enhanced Raman Scattering [PDF]
, 2013 Label free imaging of the chemical environment of biological specimens would readily bridge the supramolecular and the cellular scales, if a chemical fingerprint technique such as Raman scattering can be coupled with super resolution imaging.
Ayas, S +14 more
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Three-dimensional forward-scattering imaging flow cytometry system for single-cell analysis [PDF]
APL PhotonicsLabel-free single-cell 3D imaging is essential for accurate phenotyping by minimizing perturbations to native cellular states and facilitating downstream molecular analyses.
Yu-Hwa Lo +7 more
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