Label-free 3D molecular imaging of living tissues using Raman spectral projection tomography
Nature CommunicationsThe ability to image tissues in three dimensions (3D) with label-free molecular contrast at the mesoscale would be a valuable capability in biology and biomedicine.
Elzbieta Stepula +10 more
doaj +1 more source
Combined Lab-on-a-Chip and microarray approach for biomolecular interaction sensing using surface plasmon resonance imaging [PDF]
, 2007 Surface plasmon resonance imaging (SPR) is a well-established label-free detection technique for real-time biomolecular interaction measurements.
Berg, A. van den +6 more
core +1 more source
Nanoparticle Classification in Wide-field Interferometric Microscopy by Supervised Learning from Model [PDF]
, 2017 Interference enhanced wide-field nanoparticle imaging is a highly sensitive technique that has found numerous applications in labeled and label-free sub-diffraction-limited pathogen detection.
Avci, Oguzhan +2 more
core +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li +9 more
wiley +1 more source
Label-free photoacoustic imaging of glassfrog development
PhotoacousticsA primary focus of contemporary biology is to understand how internal molecules influence natural development. Many amphibians serve as highly effective model organisms for this research due to their rapid growth rates and transparent tissues, which ...
Qiangzhou Rong +8 more
doaj +1 more source
Using neural networks for high-speed blood cell classification in a holographic-microscopy flow-cytometry system [PDF]
, 2015 High-throughput cell sorting with flow cytometers is an important tool in modern clinical cell studies. Most cytometers use biomarkers that selectively bind to the cell, but induce significant changes in morphology and inner cell processes leading ...
Bienstman, Peter +4 more
core +2 more sources
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Quantitative phase imaging with a multimode fiber
APL PhotonicsLabel-free quantitative phase imaging is vital for optical microscopy and metrology applications. A multimode fiber stands out as a desirable platform for imaging.
Aleksandra Ivanina +4 more
doaj +1 more source
Deep learning classification of lipid droplets in quantitative phase images.
PLoS ONE, 2021 We report the application of supervised machine learning to the automated classification of lipid droplets in label-free, quantitative-phase images. By comparing various machine learning methods commonly used in biomedical imaging and remote sensing, we ...
Luke Sheneman +2 more
doaj +1 more source
Optical excitation and detection of neuronal activity [PDF]
, 2017 Optogenetics has emerged as an exciting tool for manipulating neural activity, which in turn, can modulate behavior in live organisms. However, detecting the response to the optical stimulation requires electrophysiology with physical contact or ...
Gillette, Martha +8 more
core +2 more sources