Results 51 to 60 of about 856,482 (219)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Evaluation of Breakthrough Development Effectiveness in Ten Key Areas of China's Manufacturing Industry [PDF]
中国工程科学Manufacturing is the foundation of a country. Made in China 2025 has identified ten key areas as the core engine for the transformation and upgrading of China's manufacturing industry.
Liheng Wang +9 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Research on the Construction of Learning Health System in China [PDF]
中国工程科学The health system in China has progressed to a new phase of development; however, it continues to face challenges such as uneven distribution of resources and insufficient coordination among service sectors.
Xi Li +5 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Prospect on Application of Deep-Sea Engineering Technology in Deep-Space Exploration [PDF]
中国工程科学With the further development of deep-space, deep-sea, and deep-ground technologies, numerous technical connections are found existing between deep-sea engineering and deep-space exploration and thus it is feasible to apply deep-sea engineering ...
Hao Zhang +6 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Key Technologies and Innovative Applications of Special Unmanned Aerial Vehicles [PDF]
中国工程科学Special unmanned aerial vehicles (UAVs) are UAVs designed, modified, or equipped with special equipment to satisfy special task requirements in fields such as military defense, emergency rescue, and special industries.
Changle Xiang +7 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Development Achievements and Future Prospects of Advanced Rail Transit Equipment [PDF]
中国工程科学Advanced rail transit equipment is crucial for boosting China's strength in manufacturing and transportation development. Considering global technological evolution directions of rail transit equipment and based on the landscape and high-quality ...
Rongjun Ding +6 more
doaj +1 more source