Results 61 to 70 of about 856,482 (219)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Development Strategy for Intelligent Resilience of Underground Space System in Megacities [PDF]

中国工程科学
The development of underground spaces in megacities is crucial for alleviating urban land pressure, optimizing transportation, and enhancing resilience.
Kaihang Han, Junxuan Li, Xiangsheng Chen, Yinfu Jin, Xingtao Lin, Nan Zhang, Xi Chen, Dong Su, Xiaohua Bao, Hongzhi Cui   +9 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

High-end, Intelligent, Green, and Integrated: Strategic Directions and Technological Pathways for the Innovative Development of China's Manufacturing Industry [PDF]

中国工程科学
Manufacturing is the lifeblood of a country’s economy, as well as the cornerstone of a nation. China has formulated and advanced a national strategy of new-type industrialization and a three-step roadmap for boosting China’s strength in manufacturing ...
Ji Zhou, Gaofeng Zhu, Liheng Wang, Hequan Wu, Yong Gan, Peigen Li, Zhihua Zhong, Zhongqin Lin, Zheng You, Jianfeng Chen, Xuedong Chen, Haibin Yu, Huayong Yang, Shuxin Wang, Guoqing Wang, Qingxue Huang, Xin Chen, Hong Yang, Xianming Qu, Yanhong Zhou, Jiyuan Zang   +20 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Development and Utilization of Unconventional Water Resources in the Yellow River Basin: Challenges and Strategies [PDF]

中国工程科学
In recent years, the intensive utilization of water resources in the Yellow River basin has significantly improved, with the development scale of unconventional water resources continuously expanding.
Shan Jiang, Hao Wang, Fan He, Guohua He, Yongnan Zhu, Yaqin Qiu, Lichuan Wang, Lizhen Wang   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Pathways for Water-Adaptive Development of Modern Coal Chemical Industry in the Jiziwan Region of the Yellow River Basin [PDF]

中国工程科学
The Jiziwan region in the Yellow River basin serves as the strategic core of China's modern coal chemical industry; however, sustainable development of the region is severely constrained by limited water resources.
Yufeng Yang, Shuyue Yang, Zhijun Jin, Shuyi Hu, Bo Zhang, Xinyu Li, Ziyi Diao, Xiao Han, Ying Gao, Zhuoru Shi, Zhe Zhang, Hailu Su, Yang Liu, Weiwei Wang   +13 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source