Results 71 to 80 of about 666,217 (308)

Efficacy and safety of nelfinavir in asymptomatic and mild COVID-19 patients: a structured summary of a study protocol for a multicenter, randomized controlled trial

Trials, 2021
Objectives The aim of this trial is to evaluate the antiviral efficacy, clinical efficacy, and safety of nelfinavir in patients with asymptomatic and mild COVID-19.
Naoki Hosogaya, Taiga Miyazaki, Yuri Fukushige, Sachiko Takemori, Shinpei Morimoto, Hiroshi Yamamoto, Makoto Hori, Tomoya Kurokawa, Yohei Kawasaki, Michiko Hanawa, Yasuhisa Fujii, Hideki Hanaoka, Shingo Iwami, Koichi Watashi, Satoshi Yamagoe, Yoshitsugu Miyazaki, Takaji Wakita, Koichi Izumikawa, Katsunori Yanagihara, Hiroshi Mukae, Shigeru Kohno, Nelfinavir Study Group   +21 more
doaj   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Vertex labeling and routing in expanded Apollonian networks [PDF]

, 2006
We present a family of networks, expanded deterministic Apollonian networks, which are a generalization of the Apollonian networks and are simultaneously scale-free, small-world, and highly clustered. We introduce a labeling of their vertices that allows
Ahuja R, André Raspaud, Beineke L W, Bianconi G, Bloom G S, Comellas F Fertin G Raspaud A Fraigniaud P Sibeyn J, Dorogovtsev S N, Francesc Comellas, Gallian J A, Guillaume Fertin, Lili Rong, Proskurowski A, Shuigeng Zhou, Zhang Z Z, Zhang Z Z, Zhang Z Z, Zhongzhi Zhang   +16 more
core   +3 more sources

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Paraffin embedding of the whole human cerebral hemisphere to assess arterial distribution territories

EXCLI Journal : Experimental and Clinical Sciences
Commonly used to decode the human brain's structural complexity, ex vivo dissection focuses on a given structure or region but cannot depict the whole brain organization (for example, its arterial distribution territories).
Mykyta Smirnov, Frédéric Andersson, Laurent Barantin, Igor Lima Maldonado, Christophe Destrieux   +4 more
doaj   +1 more source

Efficacy and safety of Anluohuaxian in the treatment of patients with severe Coronavirus disease 2019- a multicenter, open label, randomized controlled study: a structured summary of a study protocol for a randomised controlled trial

Trials, 2020
Objectives Patients with severe COVID-19 often suffer from significant pulmonary fibrosis. Although the pathogenesis of pulmonary fibrosis has not been fully explained, the signal pathways and cytokines involved are very similar to hepatic fibrosis. This
Chi Zhang, Jiawen Li, Zhao Wu, He Wang, Chengli Que, Hong Zhao, Guiqiang Wang   +6 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

A multifaceted intervention to reduce antibiotic prescribing among CHIldren with acute COugh and respiratory tract infection: the CHICO cluster RCT

Health Technology Assessment, 2023
Background Clinical uncertainty in primary care regarding the prognosis of children with respiratory tract infections contributes to the unnecessary use of antibiotics.
Peter S Blair, Grace J Young, Clare Clement, Padraig Dixon, Penny Seume, Jenny Ingram, Jodi Taylor, Jeremy Horwood, Patricia J Lucas, Christie Cabral, Nick A Francis, Elizabeth Beech, Martin Gulliford, Sam Creavin, Janet A Lane, Scott Bevan, Alastair D Hay   +16 more
doaj   +1 more source

POPE: Partial Order Preserving Encoding [PDF]

, 2016
Recently there has been much interest in performing search queries over encrypted data to enable functionality while protecting sensitive data. One particularly efficient mechanism for executing such queries is order-preserving encryption/encoding (OPE ...
Apon, Daniel, Choi, Seung Geol, Roche, Daniel S., Yerukhimovich, Arkady   +3 more
core   +2 more sources

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source