Results 261 to 270 of about 2,832,374 (333)

Hydrogel Adhesive Integrated‐Microstructured Electrodes for Cuff‐Free, Less‐Invasive, and Stable Interface for Vagus Nerve Stimulation

Advanced Healthcare Materials, EarlyView.
In this study, a cuff‐free, less‐invasive surgical approach for vagus nerve stimulation (VNS) by combining ultrathin Y‐shaped kirigami electrodes is developed with a chemically cross‐linked hydrogel adhesive (hydrogel‐kirigami). Unlike conventional cuff implantation, which may damage nerves and nearby critical vessels, this new technique minimizes ...
Jae Young Park, Jongcheon Lim, Carl R. Russell III, Pei‐Lun Chen, Deniz Eksioglu, Seokkyoon Hong, Juan C. Mesa, Matthew P. Ward, Chi Hwan Lee, Hyowon Lee   +9 more
wiley   +1 more source

Efficacy and safety of once‐weekly oral trelagliptin switched from once‐daily dipeptidyl peptidase‐4 inhibitor in patients with type 2 diabetes mellitus: An open‐label, phase 3 exploratory study

, 2017
Nobuya Inagaki, Hiroki Sano, Yoshifumi Seki, Shingo Kuroda, Kohei Kaku   +4 more
openalex   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Co‐Delivery of Multiple Toll‐Like Receptor Agonists and Avian Influenza Hemagglutinin on Protein Nanoparticles Enhances Vaccine Immunogenicity and Efficacy

Advanced Healthcare Materials, EarlyView.
This research highlights a novel application of protein nanoparticles to effectively modulate the strength, breadth, and bias of an immune response against influenza virus. Nanoparticles precisely co‐delivering antigen (H5) and multiple adjuvants (CpG and FliCc) present a way to improve and direct prophylactic immune responses which can be applicable ...
Aaron Ramirez, Jenny E. Hernandez‐Davies, Aarti Jain, Lu Wang, Erwin Strahsburger, D. Huw Davies, Szu‐Wen Wang   +6 more
wiley   +1 more source

In Vivo‐Like Scaffold‐Free 3D In Vitro Models of Muscular Dystrophies: The Case for Anchored Cell Sheet Engineering in Personalized Medicine

Advanced Healthcare Materials, EarlyView.
The scaffold‐free Anchored Cell Sheet Engineering platform is used to create three‐dimensional (3D) in vitro models of skeletal muscle tissue that replicate key features of Duchenne and Myotonic dystrophies. These personalized tissue models, validated by histological, immunostaining, and proteomics analyses, accurately mimic disease phenotypes and ...
Alireza Shahin‐Shamsabadi, John Cappuccitti   +1 more
wiley   +1 more source

A general strategy for label-free homogeneous bioassays based on selective recognition and silver ion-mediated conformational switch

, 2019
Piaopiao Chen, Erica Sawyer, Ke Sun, Xialin Zhang, Chuan Chen, Binwu Ying, Xiawei Wei, Zhengzhi Wu, Jia Geng   +8 more
openalex   +1 more source

CircAars‐Engineered ADSCs Facilitate Maxillofacial Bone Defects Repair Via Synergistic Capability of Osteogenic Differentiation, Macrophage Polarization and Angiogenesis

Advanced Healthcare Materials, EarlyView.
Schematic representation of circAars‐engineered‐ADSCs incorporated into GelMA scaffolds for craniomaxillofacial bone regeneration. CircAars‐engineered ADSCs embedded in GelMA scaffolds enhance the repair of critical‐sized bone defects by binding miR‐128‐3p in the cytoplasm, thereby inhibiting its activity.
Yi He, Yunyang Lu, Runze Li, Yuquan Tang, Weidong Du, Lejia Zhang, Jie Wu, Kechen Li, Weijie Zhuang, Shiyu Lv, Yaoling Han, Bailong Tao, Feilong Deng, Wei Zhao, Dongsheng Yu   +14 more
wiley   +1 more source

Validation of Slow Off-Kinetics of Sirtuin Rearranging Ligands (SirReals) by Means of the Label-Free Electrically Switchable Nanolever Technology

, 2019
Matthias Schiedel, Herwin Daub, Aymelt Itzen, Manfred Jung   +3 more
openalex   +1 more source

Matrix Viscoelasticity Orchestrates Osteogenesis via Mechanotransduction Mediated Metabolic Switch in Macrophages

Advanced Healthcare Materials, EarlyView.
Fast‐relaxation viscoelastic hydrogel triggers a metabolic shift in macrophages, favoring oxidative phosphorylation (OXPHOS) over glycolysis via vasodilator‐stimulated phosphoprotein (VASP) / hypoxia‐inducible factor 1 alpha (HIF1α) signaling meditated mechanotransdution, thereby enhancing their capacity to recruit mesenchymal stem cells (MSCs) and ...
Dihao Tao, Hanzhe Wang, Shiping Chang, Jiayu Cheng, Ningning Da, Li Zhang, Jianhua Yang, Wenzhe Wang, Feng Xu, Bei Li   +9 more
wiley   +1 more source

Enhancing Form Stability: Shrink‐Resistant Hydrogels Made of Interpenetrating Networks of Recombinant Spider Silk and Collagen‐I

Advanced Healthcare Materials, EarlyView.
A shrinkage‐resistant hydrogel is developed to confer post‐fabrication shape fidelity. The hydrogel, based on recombinant spider silk protein eADF4(C16)‐RGD and collagen‐I, exhibits tunable mechanical properties and shrink‐resistance in the presence of fibroblasts as well as muscle cells.
Xuen J. Ng, Tilman U. Esser, Vanessa T. Trossmann, Christoph Rudisch, Maren Fiedler, Kaveh Roshanbinfar, Zan Lamberger, Philipp Stahlhut, Gregor Lang, Thomas Scheibel, Felix B. Engel   +10 more
wiley   +1 more source