Results 81 to 90 of about 2,965,444 (278)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Automatic road digital twinning from semantically labeled point cloud data

Journal of Intelligent Construction
Creating geometric digital twins (gDTs) for as-built roads still has many limitations, such as low automation level and accuracy, limited asset types and shapes, and reliance on engineering experience.
Yuexiong Ding, Mengtian Yin, Ran Wei, Ioannis Brilakis, Muyang Liu, Xiaowei Luo   +5 more
doaj   +1 more source

On Data Labeling for Clustering Categorical Data

IEEE Transactions on Knowledge and Data Engineering, 2008
Sampling has been recognized as an important technique to improve the efficiency of clustering. However, with sampling applied, those points which are not sampled will not have their labels after the normal process. Although there is a straightforward approach in the numerical domain, the problem of how to allocate those unlabeled data points into ...
Chen, H.-L., Chuang, K.-T., Chen, M.-S.
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Model Reuse in Machine Learning for Author Name Disambiguation: An Exploration of Transfer Learning

IEEE Access, 2020
Machine learning for author name disambiguation is usually conducted on the training and test subsets of labeled data created for a specific task. As a result, disambiguation models learned on heterogeneous labeled data are often inapplicable for other ...
Jinseok Kim, Jason Owen-Smith
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Self-Supervised Learning for Vehicle Noise Prediction With Limited Labeled Data

IEEE Access
With advancements in artificial intelligence, its application for developing quieter vehicles is increasingly researched in the automotive industry.
Sunhyeok Hwang, Seoung Bum Kim
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Classification of Few Labeled Images Based on Integrated GMM Clustering

Xibei Gongye Daxue Xuebao, 2019
In order to improve the classifier classification accuracy of by using convolutional neural network training, a large amount of labeled data is often required, but sometimes labeled data is not easily obtained.This paper proposes a solution based on the ...

doaj   +1 more source