Results 131 to 140 of about 187,141 (267)

Measuring recent in-country TB transmission using a classification model with whole genome sequencing data. [PDF]

IJTLD Open
Frederiks W, Anthony RM, de Vries G.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Studying exogenous extracellular vesicle biodistribution by in vivo fluorescence microscopy

Disease Models & Mechanisms, 2023
Sien Yee Lau, Matthew Kang, Colin L. Hisey, Lawrence W. Chamley   +3 more
doaj   +1 more source

Surfaceome Capture by Multiplex Biotinylation Enables Enhanced Identification of Cell Surface Proteins by Mass Spectrometry. [PDF]

Mol Cell Proteomics
Levi A, Shields T, I Badshah I, Rajeeve V, Cutillas PR.   +4 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Detection of a group of classic serum tumor markers (CSTMs) aids in the differential diagnosis and disease assessment of upper tract urothelial carcinoma (UTUC). [PDF]

Transl Androl Urol
Pan JW, Qi F, Jin XW, Tu WC, Wang XJ, Zhang X, Chen YH, Huang BX, Luo FX, Xu DF, Shao Y.   +10 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Characterisation of cold-selective lamina I spinal projection neurons in the mouse. [PDF]

Elife
Razlan AN, Ma W, Dickie AC, Polgar E, McFarlane AG, Yadav M, Cooper AH, Strathdee D, Watanabe M, Bell AM, Todd AJ, Hachisuka J.   +11 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Single-EV Analyses Require Rigorous Antibody Qualification: PD-L1 Profiling in Cell Models and Patient Plasma. [PDF]

J Extracell Biol
Tertel T, Bauer FN, Stambouli O, Kasimir-Bauer S, Keup C, Lang S, Sak A, Stuschke M, Rassaf T, Schuler M, Kasper-Virchow S, Giebel B, Schramm A.   +12 more
europepmc   +1 more source