Results 241 to 250 of about 290,195 (301)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Site-specific labelling of native peptides and proteins: chemical and enzymatic strategies. [PDF]

Beilstein J Org Chem
Angelastro A, Bargh J, Guria S, Laserna V, Luk L.   +4 more
europepmc   +1 more source

The Biodistribution of ^99mTc Labelled Equine Peripheral Blood Mesenchymal Stem Cells in Healthy and Chronic Gingivostomatitis Cats. [PDF]

Vet Sci
Beerts C, Debosschere Y, Tack L, Pauwelyn G, Carlier S, Depuydt E, Saunders JH, Peremans K, Spaas JH.   +8 more
europepmc   +1 more source

Extensive sucrose cycling through the fructan pool of a C3 grass across a 200 to 800 μmol mol-1 atmospheric CO2 gradient. [PDF]

Plant Physiol
Zhu J, Lehmeier CA, Ostler U, Hirl RT, Baca Cabrera JC, Schäufele R, Lattanzi FA, Schnyder H.   +7 more
europepmc   +1 more source

Intersecting stigma, social exclusion and coping mechanisms among women living with obstetric fistula in rural northern Ghana: a qualitative study. [PDF]

Front Reprod Health
Abilla NS, Asiedua E, Pwavra JBP, Issah S, Senkyire E.   +4 more
europepmc   +1 more source

A Practical Perspective on Confronting the Obesity Epidemic: Public-Health Strategies. [PDF]

Nutrients
Owczarczyk-Durma AC, Czupryniak L.
europepmc   +1 more source

Heart failure detection in electrocardiograms using artificial intelligence and pragmatic labelling. [PDF]

NPJ Digit Med
Stenhede E, Ravn J, Schirmer H, Ranjbar A.   +3 more
europepmc   +1 more source

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To Label or Not to Label

JAMA: The Journal of the American Medical Association, 1967
ABSTRACT To the Editor:— A pharmaceutical firm advertises its identification code for its drug products, with the suggestion that this code could be lifesaving. Other devices could be equally lifesaving. A recent note in The Journal states that pharmacists need not label prescriptions unless requested by the physician to do so.
openaire   +4 more sources