Results 101 to 110 of about 1,805,523 (250)

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Gig Work and Labor Market Uncertainty: A Bibliometric Review of Employment Insecurity and Worker Well-Being

Jurnal Ilmu Sosial dan Humaniora
The rapid expansion of the gig economy and platform-based work has transformed labor markets by increasing flexibility while simultaneously intensifying labor market uncertainty and employment insecurity, raising concerns about mental well-being and ...
Axellina Muara Setyanti, Muhammad Fansurullah Harsa   +1 more
doaj   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Supramolecular Terbium‐Threonine Chiral Emitters with Tunable Circularly Polarized Luminescence as Anticounterfeiting‐Ink for Autonomous Data Encryption

Advanced Science, EarlyView.
A one‐pot, aqueous, and scalable method for synthesizing chiral lanthanide supramolecular emitters using terbium and threonine is reported. The aqueous solution of these chiral emitters displays the following features: (i) 100 % transparency, (ii) tunable luminescence and CPL, and (iii) a pH feedback loop that controls the “on‐off” states of ...
P. M. Ajay Sekhar, Nidhin Ravi, Kaloor S. Harikrishnan, Jim Bachmann, Nikos L. Doltsinis, Reji Varghese   +5 more
wiley   +1 more source

Northwest Labor Press (Print Edition)-10-03-2014

, 2014
The Northwest Labor Press is an independent, union-supported newspaper. The print edition is mailed out twice a month to over 50,000 members of more than 80 unions in Oregon and Southwest Washington. The online edition has been maintained at nwlaborpress.
Northwest Labor Press
core  

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Microeconomic Flexibility in India and Pakistan: Employment Adjustment at the Firm Level

Lahore Journal of Economics
In this paper, we look at the pace at which firms adjust their employment levels as a measure of “microeconomic flexibility.” Flexibility aids in creative destruction processes, where less efficient establishments recede and dynamic firms can rapidly ...
Theresa Chaudhry
doaj  

Northwest Labor Press (Print Edition)-09-04-2009

, 2009
The Northwest Labor Press is an independent, union-supported newspaper. The print edition is mailed out twice a month to over 50,000 members of more than 80 unions in Oregon and Southwest Washington. The online edition has been maintained at nwlaborpress.
Northwest Labor Press
core  

AI‐Powered, Temperature‐Resolved Centrifugal Microfluidics for Rapid 3D Phase‐Diagram Generation of Biomolecular Condensates

Advanced Science, EarlyView.
By merging centrifugal microfluidics, precise temperature control, and AI image recognition, T‐PhaseMap transforms biomolecular condensate phase mapping into a rapid, temperature‐resolved workflow. It generates 3D composition–temperature phase diagrams within 30 min, resolves four phase states, and uncovers temperature‐dependent heparin sodium ...
Jiashuo Li, Pengjie Li, Kaiting Zhang, Yongqi Guo, Peng Chen, Bi‐Feng Liu, Yiwei Li   +6 more
wiley   +1 more source

Northwest Labor Press (Print Edition)-04-05-2019

, 2019
The Northwest Labor Press is an independent, union-supported newspaper. The print edition is mailed out twice a month to over 50,000 members of more than 80 unions in Oregon and Southwest Washington. The online edition has been maintained at nwlaborpress.
Northwest Labor Press
core