Results 71 to 80 of about 1,338,765 (261)

Evaluating the Performance of the Laboratory Information System of Public Hospitals in Shiraz, 2011 [PDF]

Interdisciplinary Journal of Virtual Learning in Medical Sciences, 2012
Introduction: The Laboratory Information System is a computerized information system which manages laboratory data in the fields of clinical chemistry, hematology, microbiology, etc.
Mohtaram Nematollahi, Hamideh Kharmandar, Mohammad Reza Mohammad Ameripoor   +2 more
doaj  

Learning in the Science Lab: a New Approach

Irish Journal of Academic Practice, 2012
This project aimed to improve the laboratory learning experience for undergraduate science students, focusing initially on first and third year cohorts, through specific objectives. Firstly, to incorporate novel teaching and assessment methods, including
Barry Ryan, Julie Dunne
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The scourge of antimicrobial resistance: Containing a global crisis

African Journal of Laboratory Medicine
No abstract available.
Rajiv T. Erasmus, Chikwelu L. Obi, Sajini Souda   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

ETHNOS: A versatile electronic tool for the development and curation of national genetic databases

Human Genomics, 2010
National and ethnic mutation databases (NEMDBs) are emerging online repositories, recording extensive information about the described genetic heterogeneity of an ethnic group or population. These resources facilitate the provision of genetic services and
van Baal Sjozef, Zlotogora Joël, Lagoumintzis George, Gkantouna Vassiliki, Tzimas Ioannis, Poulas Konstantinos, Tsakalidis Athanassios, Romeo Giovanni, Patrinos George P   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Laboratory experiments

, 2023
Laboratory experiments belong in the methodical tool box of modern sociological scholarship. This chapter reviews the main points that researchers wanting to conduct a computerized, behavioral laboratory experiment should take into consideration. In particular, the chapter discusses (1) the organization of experimental sessions, (2) the set-up of ...
openaire   +1 more source