Results 91 to 100 of about 2,504,342 (301)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Rhythms of Locomotion Expressed by Limulus polyphemus, the American Horseshoe Crab: II. Relationship to Circadian Rhythms of Visual Sensitivity [PDF]

, 2008
In the laboratory, horseshoe crabs express a circadian rhythm of visual sensitivity as well as daily and circatidal rhythms of locomotion. The major goal of this investigation was to determine whether the circadian clock underlying changes in visual ...
Bedford, Lisa, Chabot, Christopher C., Watson, Winsor H., III   +2 more
core   +3 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Living with Transgenic Animals [PDF]

, 2014
This article examines Farm Sanctuary’s failed effort to save the Enviropigs. In the Spring of 2012, after losing the main source of funding for its Enviropig project, the University of Guelph, in Ontario, Canada, killed the last sixteen members of this ...
Jonathan L. Clark
core   +1 more source

Chlamydia (Chlamydophila) pneumoniae in animals: a review

Veterinární Medicína, 2004
An important discovery in the last couple of years is that humans are not the only natural hosts with which C. pneumoniae is the primary cause for the disease. Successively, the C.
L. Pospisil, J. Canderle
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A Pathway Analysis Tool for Analyzing Microarray Data of Species with Low Physiological Information [PDF]

, 2008
Pathway information provides insight into the biological processes underlying microarray data. Pathway information is widely available for humans and laboratory animals in databases through the internet, but less for other species, for example, livestock.
Pas, M.F.W., te, Hemert, S., van, Hulsegge, B., Hoekman, A.J.W., Pool, M.H., Rebel, J.M.J., Smits, M.A.   +6 more
core   +3 more sources

Blood Sampling from Laboratory Rabbits

مجله دانشکده پزشکی اصفهان, 2015
Background: Proper method of blood collection (BC) has significant consequences in many biological productions and research activities. Due to the challenges of blood collection from laboratory rabbits, cardiac puncture is routinely performed as the ...
Siavash Ahmadi-Noorbakhsh, Esmat Mirabzadeh-Ardakani   +1 more
doaj  

Analysis of Institutional Characteristics and Implementation of Guangdong Province Laboratory Animals Ordinance in the Past Decade

Shiyan dongwu yu bijiao yixue
The Guangdong Province Laboratory Animals Ordinance (the GPLAO), officially enacted and implemented in October 2010, marked a new phase of legal management in the administration of laboratory animals in Guangdong Province.
DENG Shaochang, LIN Danrong, LIANG Chujun, LEI Weiqiao, YANG Jinchun, ZHAO Weibo   +5 more
doaj   +1 more source

Forensic luminol reaction for detecting fecal occult blood in experimental mice

BioTechniques, 2018
Fecal occult blood (FOB) is a sign of gastrointestinal diseases, such as intestinal ulcers and colorectal cancer. In experimental animal studies, there is no standard method to detect FOB.
Ah-Mee Park, Ikuo Tsunoda
doaj   +1 more source