Results 81 to 90 of about 1,631,615 (310)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Chlamydia (Chlamydophila) pneumoniae in animals: a review

open access: yesVeterinární Medicína, 2004
An important discovery in the last couple of years is that humans are not the only natural hosts with which C. pneumoniae is the primary cause for the disease. Successively, the C.
L. Pospisil, J. Canderle
doaj   +1 more source

Protecting Animals 42: Larry Carbone

open access: yes, 2019
This episode of Knowing Animals is from the Protecting Animals series. We are joined by Larry Carbone. Larry is US based. He is a vet who has worked with laboratory animals for many years.
Carbone, Larry, O'Sullivan, Siobhan
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Blood Sampling from Laboratory Rabbits

open access: yesمجله دانشکده پزشکی اصفهان, 2015
Background: Proper method of blood collection (BC) has significant consequences in many biological productions and research activities. Due to the challenges of blood collection from laboratory rabbits, cardiac puncture is routinely performed as the ...
Siavash Ahmadi-Noorbakhsh   +1 more
doaj  

Analysis of Institutional Characteristics and Implementation of Guangdong Province Laboratory Animals Ordinance in the Past Decade

open access: yesShiyan dongwu yu bijiao yixue
The Guangdong Province Laboratory Animals Ordinance (the GPLAO), officially enacted and implemented in October 2010, marked a new phase of legal management in the administration of laboratory animals in Guangdong Province.
DENG Shaochang   +5 more
doaj   +1 more source

Forensic luminol reaction for detecting fecal occult blood in experimental mice

open access: yesBioTechniques, 2018
Fecal occult blood (FOB) is a sign of gastrointestinal diseases, such as intestinal ulcers and colorectal cancer. In experimental animal studies, there is no standard method to detect FOB.
Ah-Mee Park, Ikuo Tsunoda
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Preparation of Ethic codes for studies on laboratory animals

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2006
In most of research programs, uses of laboratory animals are necessary. For this reason we have to prepare comfortable and health situation near their natural life for animals in laboratory.
SJ Ale davoud   +6 more
doaj  

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