Results 131 to 140 of about 2,504,342 (301)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
, 1989 Livestock rations should be balanced for many parameters including protein, and various minerals, and energy, to ensure that all required nutrients are present in the adequate amounts and proper relationships. Energy content is the primary consideration
Bruce, Leroy Ben, Herlugson, Mary Lou
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Virology JournalSwine acute diarrhoea syndrome coronavirus (SADS-CoV) causes vomiting, severe diarrhoea and death in newborn piglets. The spike (S) protein plays a crucial role in promoting virus invasion and inducing neutralizing antibody production. In this study, the
Lin Zhang +6 more
doaj +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Reducing Animal Numbers in a Contact Sentinel Program [PDF]
, 2012 Rodent health surveillance using sentinel animals is a critical part of the preventative health program for most laboratory rodent facilities. Introduction of animals through a quarantine area is generally one of the highest biosecurity risk areas in ...
Adkins, M., Baer, J., Lencioni, K.
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Siberian Journal of Life Sciences and AgricultureBackground. The study of the activation process of hair papilla stem cells when using regeneration stimulators to improve the structure of the hair and its growth rate is relevant both for the development of drugs for fur farming and alopecia treatment ...
Olga B. Zhdanova +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Methodology for estimation of total body composition in laboratory mammals [PDF]
A standardized dissection and chemical analysis procedure was developed for individual animals of several species in the size range mouse to monkey (15 g to 15 kg). The standardized procedure permits rigorous comparisons to be made both interspecifically
Pace, N., Rahlmann, D. F., Smith, A. H.
core +1 more source
Lingual development of dysplastic and neoplastic lesions in laboratory animals [PDF]
, 2015 Los modelos experimentales juegan un papel importante en las ciencias biomédicas en la elucidación de la patogénesis de diferentes trastornos que afectan a los organismos vivos, incluyendo los seres humanos y también son útiles para: el estudio de la ...
Cavicchia, Juan Carlos +1 more
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source