Results 141 to 150 of about 1,641,794 (309)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Use of Laboratory Animals [PDF]

, 1999
Hauswald, Mark
core   +1 more source

Incidence of Spontaneous Ocular Lesions in Laboratory Animals. [PDF]

J Am Assoc Lab Anim Sci
Cheng H, Gao J, Zhou Y.
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

A review of spontaneous bone metastases in domestic and laboratory animals. [PDF]

J Bone Oncol
Yuan S, Hoggard NK, Keller ET, Matz BM, Wei S, Fan TM, Hildreth BE, Rosol TJ.   +7 more
europepmc   +1 more source

Morphometrics of Xenopus laevis Kept as Laboratory Animals. [PDF]

Animals (Basel), 2022
Böswald LF, Matzek D, Mohr H, Kienzle E, Popper B.   +4 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Comprehensive methodology for evaluating the immobility responses in laboratory animals. [PDF]

MethodsX
Estrada-Silva MA, Cruz-Rodríguez J, Silva-Luna G, Torres-Mendoza JN, Luna-Tenorio E, Luna-Viramontes NI, Vázquez-Vargas ID, Granados-Rivas B, Luna-Muñoz J, Flores G, Ramírez LG, la Cruz-López F.   +11 more
europepmc   +1 more source

Sheep as a large animal model for hearing research: comparison to common laboratory animals and humans. [PDF]

Lab Anim Res, 2023
Lue PY, Oliver MH, Neeff M, Thorne PR, Suzuki-Kerr H.   +4 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source