Results 141 to 150 of about 1,631,615 (310)

Sheep as a large animal model for hearing research: comparison to common laboratory animals and humans. [PDF]

Lab Anim Res, 2023
Lue PY, Oliver MH, Neeff M, Thorne PR, Suzuki-Kerr H.   +4 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Comprehensive methodology for evaluating the immobility responses in laboratory animals. [PDF]

MethodsX
Estrada-Silva MA, Cruz-Rodríguez J, Silva-Luna G, Torres-Mendoza JN, Luna-Tenorio E, Luna-Viramontes NI, Vázquez-Vargas ID, Granados-Rivas B, Luna-Muñoz J, Flores G, Ramírez LG, la Cruz-López F.   +11 more
europepmc   +1 more source

Nomenclature for standardized designation of diploid genotypes in genetically modified laboratory animals. [PDF]

Lab Anim, 2023
Dobrowolski P, Buch T, Nagel-Riedasch S.
europepmc   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

How University Students Evaluate the Use of Laboratory Animals: The Role of Species and Individual Differences. [PDF]

Animals (Basel)
Ruiz-Sancho L, Saez-Atxukarro O, Gomez-Gastiasoro A, Azkona G.   +3 more
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

General anesthesia and depth of anesthesia (DoA) evaluation methods in laboratory animals: a comprehensive review. [PDF]

Vet Res Commun
Altınoluk T, Kazdağlı H.
europepmc   +1 more source

Refinements in rabbit husbandry Second report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement

, 1993
Reprinted from Laboratory animals 1993 vol 27, pages 301-329Available from British Library Document Supply Centre-DSC:m00/36085 / BLDSC - British Library Document Supply CentreSIGLEGBUnited ...
Laboratory Animals Ltd., London (United Kingdom)
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source