Results 91 to 100 of about 9,887,563 (334)

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Experimental Study on the Effect of Wind on Armor Stone Stability

open access: yesJournal of Marine Science and Engineering
Wind is a significant factor influencing the stability of breakwater armor stones. However, few existing studies have considered the effects of wind on these structures.
Young-Min Kim   +2 more
doaj   +1 more source

Fermentation Gone Wild: A Biochemistry Laboratory Experiment. [PDF]

open access: yesJ Chem Educ, 2023
Millard JT   +3 more
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Social Exchange Networks: A Review of Experimental Studies [PDF]

open access: yesConnections, 2016
Sabine Neuhofer   +2 more
doaj   +1 more source

Photogrammetric Investigation of Storm-Induced Erosion Process on Sandy Beach Profile in Medium-Scale Flume

open access: yesJournal of Marine Science and Engineering
In this study, laboratory experiments were conducted to investigate the influence of changes in storm wave height and water level on beach response in a medium-scale wave flume. A schematic storm was simulated (rising, apex, and waning phases).
Jun Wang   +5 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

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