Results 121 to 130 of about 3,152,535 (345)

The spacecraft control laboratory experiment optical attitude measurement system [PDF]

open access: yes
A stereo camera tracking system was developed to provide a near real-time measure of the position and attitude of the Spacecraft COntrol Laboratory Experiment (SCOLE).
Barsky, Michael F.   +2 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Photogrammetric Investigation of Storm-Induced Erosion Process on Sandy Beach Profile in Medium-Scale Flume

open access: yesJournal of Marine Science and Engineering
In this study, laboratory experiments were conducted to investigate the influence of changes in storm wave height and water level on beach response in a medium-scale wave flume. A schematic storm was simulated (rising, apex, and waning phases).
Jun Wang   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Dynamic behaviour and energy dissipation of offline air pockets in transient pipe flows

open access: yesEngineering Applications of Computational Fluid Mechanics
The traditional one-dimensional (1D) model often fails to accurately predict the dynamic pressure response of large offline air pockets during transients, due to a lack of comprehensive understanding of the underlying mechanisms of transient interaction ...
Yun-Jie Li   +6 more
doaj   +1 more source

Description of the Spacecraft Control Laboratory Experiment (SCOLE) facility [PDF]

open access: yes
A laboratory facility for the study of control laws for large flexible spacecraft is described. The facility fulfills the requirements of the Spacecraft Control Laboratory Experiment (SCOLE) design challenge for a laboratory experiment, which will allow ...
Rallo, Rosemary A., Williams, Jeffrey P.
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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