Results 131 to 140 of about 6,220,328 (293)

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Experimental and Numerical Study on the Influence of Forest Spatial Structure on Rockfall Protection Efficacy

open access: yesApplied Sciences
With the growing emphasis on bio-engineering techniques, the sustainable advantages of using trees as barriers against rockfalls have become increasingly evident.
Haiyang Liu   +6 more
doaj   +1 more source

Narratives of the Future Affect Fertility: Evidence from a Laboratory Experiment. [PDF]

open access: yesEur J Popul, 2022
Vignoli D   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Argonne National Laboratory Report ANL-5256

open access: yes, 1954
Report issued by the Argonne National Laboratory discussing meteorological data collected between 1952 and 1953. Wind, temperature, pressure, and precipitation studies are presented.
Turner, Louis Alexander, 1898-   +1 more
core  

Leptophilic ALPs in laboratory experiments

open access: yesJournal of High Energy Physics
A bstract We study the collider phenomenology of leptophilic axion-like particles (ALPs), i.e. pseudoscalar particles that couple only to charged leptons. Loops of charged leptons induce effective interactions of the ALPs with photons, which depend on the momenta of the ...
Alexander Eberhart   +4 more
openaire   +5 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy