Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Effect of Common Mouthwashes on Mechanical Properties of Suture Materials Used in Dental Surgeries: A Laboratory Experiment. [PDF]
Polymers (Basel), 2022 Abullais SS +6 more
europepmc +1 more source
Mg-calcite dissolution in coral reefs estimated by laboratory experiment and field observation
, 2014 将史 山本
openalex +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Laboratory experiment of ATP measurement using Mars soil simulant: as a method for extraterrestrial life detection. [PDF]
Anal Sci, 2022 Enya K, Sasaki S.
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Internal and External Factors' Influence on Recycling: Insights From a Laboratory Experiment With Observed Behavior. [PDF]
Front Psychol, 2021 Linder N +3 more
europepmc +1 more source
Software for the complex for registration and processing of laboratory experiments data
, 2012 A. V. Bohdan +2 more
openalex +2 more sources
Elimination of Escherichia coli in Water Using Cobalt Ferrite Nanoparticles: Laboratory and Pilot Plant Experiments [PDF]
, 2019 Elmer Gastelo +6 more
openalex +1 more source