Results 151 to 160 of about 1,580,428 (313)

Spondylodiscitis: evaluation of patients in a tertiary hospital

, 2014
Introduction: Spondylodiscitis (SD) is an uncommon but important infection. The aim of this work was to study the risk factors, bacteriological features, clinical, laboratory and radiological findings of SD, and to shed light on the initial ...
AKTAS, Ulas, KAMASAK, Kagan, ERCAN, Serdar, CINAR, Kadir, KAYA, Safak, Eskazan, AHMET EMRE, TEMIZ, Hakan, Boyaci, Mehmet Gazi, DUYMUS, Recai, KAYA, Sehmuz, AKKOYUN, Nesrin, OZALP, Hakan   +11 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Healthcare-associated infections in a newly opened pediatric intensive care unit in Turkey: Results of four-year surveillance

, 2016
Introduction: Healthcare-associated infections (HAIs) are important causes of morbidity and mortality, especially in critically ill patients in intensive care units.
ÖZTÜRK, MAKBULE NİLÜFER, YAKUT, NURHAYAT, KEPENEKLİ KADAYİFCİ, EDA, ALTINKANAT GELMEZ, GÜLŞEN   +3 more
core   +1 more source

Brucella related myocarditis

International Journal of Infectious Diseases, 2018
Sebastian Wendt, Norman Lippmann, Jeanette Fahnert, Arne C. Rodloff, Christoph Lübbert   +4 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Long subcutaneous tunnelling reduces infection rates in paediatric external ventricular drains

, 2014
Purpose The aim of this study is to report the efficacy of long subcutaneous tunnelling of external ventricular drains in reducing rates of infection and catheter displacement in a paediatric population. Methods In children requiring external ventricular
Chakraborty, A, Collins, CDE, Thompson, DNP, Hartley, JC   +3 more
core  

Spreading of occupational allergens: laboratory animal allergens on hair-covering caps and in mattress dust of laboratory animal workers

, 2007
BACKGROUND: Family members of laboratory animal workers are at risk of developing allergy to laboratory animals. Little is known about the spreading of laboratory animal allergens outside the animal facilities.
Krop, Esmeralda J. M., van der Zee, Jaring S., Doekes, Gert, Stone, Martin J., Aalberse, Rob C.   +4 more
core   +1 more source

Two Cases of Laboratory-acquired Brucellosis

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2018
Merve Sefa SAYAR, Dilek Bulut, Aslı HAYKIR SOLAY   +2 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source