Results 41 to 50 of about 1,253,203 (304)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
GAN-based deep learning framework of network reconstruction
Complex & Intelligent Systems, 2022 Inferring the topology of a network from network dynamics is a significant problem with both theoretical research significance and practical value. This paper considers how to reconstruct the network topology according to the continuous-time data on the ...
Xiang Xu, Xianqiang Zhu, Cheng Zhu
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Design and Realization of Integrated Management System for Data Interoperability between Point-of-Care Testing Equipment and Hospital Information System [PDF]
Healthcare Informatics Research, 2013 ObjectivesThe purpose of this study was to design an integrated data management system based on the POCT1-A2, LIS2-A, LIS2-A2, and HL7 standard to ensure data interoperability between mobile equipment, such as point-of-care testing equipment and the ...
Ki Sang Park, Hyuk Heo, Young Keun Choi
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Indian Journal of Community MedicineBackground: Laboratory Information Systems like any other automated systems have been touted for their contribution in recognizing and minimizing diagnostic errors, supplementing the decision-making process and improving diagnostic outcomes Objectives ...
K B Asha +2 more
doaj +1 more source
Engaging Science, Technology, and Society, 2016 Digital systems pervade classic STS sites of interest, from connecting laboratories to mediating lay-expert divides. But STS has so far been reticent to build the theoretical and analytical perspectives necessary for embracing digital systems as an ...
Janet Vertesi
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SWIFTCORE: a tool for the context-specific reconstruction of genome-scale metabolic networks
BMC Bioinformatics, 2020 Background High-throughput omics technologies have enabled the comprehensive reconstructions of genome-scale metabolic networks for many organisms. However, only a subset of reactions is active in each cell which differs from tissue to tissue or from ...
Mojtaba Tefagh, Stephen P. Boyd
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source