Results 61 to 70 of about 1,216,010 (256)

Multi-Scale Attentive Interaction Networks for Chinese Medical Question Answer Selection

IEEE Access, 2018
The past few years have witnessed a trend that the deep learning techniques have been increasingly applied in healthcare due to the explosive growth of big data.
Sheng Zhang, Xin Zhang, Hui Wang, Lixiang Guo, Shanshan Liu   +4 more
doaj   +1 more source

Managing beyond the laboratory information system

Journal of Pathology Informatics, 2012
Sir, Prior to the advent of electronic health records (EHRs) the issue of segregating or integrating laboratory observations reported from two or more independent laboratories was of little or no concern to pathologists. However, the intersection of two realities has and will significantly increase the complexity of laboratory results management ...
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Process for Leveraging Enterprise Architecture in Information Systems Strategic Planning: A Case of Developing a Strategy and Master Plan for a National Integrated Health Laboratory Information Management System in Uganda

Complex Systems Informatics and Modeling Quarterly
Effective alignment of institutional processes with digital technologies is imperative for enterprises, including those in healthcare. Unfortunately, in the context of health laboratories, the scope and complexity of existing digital health interventions
Agnes Nakakawa, Daniel Kasule, Michael Kasusse, Gaspard Guma, Steven Aisu, Patrick A. Ogwok, Hakim Sendagire   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Implementation of a Laboratory Information System in a Simulated Laboratory

American Society for Clinical Laboratory Science, 2017
Electronic health records are the principal method of storing patient health data. Laboratory Information Systems (LIS), a portion of the EHR, are the main avenue for laboratory staff to store data and provide laboratory results to health care providers. This paper examines the implementation of an LIS in an institution where simulated laboratories are
openaire   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Evaluations of Similarity Measures on VK for Link Prediction

Data Science and Engineering, 2018
Recommender system is one of the most important components for many companies and social networks such as Facebook and YouTube. A recommendation system consists of algorithms which allow to predict and recommend friends or products. This paper studies to
JooYoung Lee, Rustam Tukhvatov
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source