Results 171 to 180 of about 8,036,410 (300)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Permanent Lipid Lowering with CRISPR-Based Interventions: Redefining Laboratory Medicine in the Era of Gene Editing. [PDF]

Clin Chem
Zubiran R, Remaley AT.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Journal of Laboratory Medicine – half a century of interesting insights into laboratory medicine

Journal of Laboratory Medicine
Lichtinghagen Ralf
doaj   +1 more source

Modern LDL-C estimation equations and therapeutic reclassification: a laboratory medicine perspective. [PDF]

Adv Lab Med
Tortosa-Carreres J, Laiz-Marro B.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Laboratory diagnostics in personalised medicine - 36th Symposium of the Croatian society of medical biochemistry and laboratory medicine. [PDF]

Biochem Med (Zagreb)
Rogić D, Šimičević L, Žigman T, Bambir I, Vukić Dugac A, Tješić-Drinković D, Fumić K, Lehman I, Rako I, Popović M, Ganoci L, Živković M, Mihaljević-Peleš A.   +12 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

iLABMED in the AI Era: Redefining Laboratory Medicine Through ChatGPT, DeepSeek and Beyond

iLABMED
Jiuxin Qu, Hongzhou Lu
doaj   +1 more source

Educational strategies for enhancing medical students' competency in laboratory medicine practice: a scoping review. [PDF]

Front Med (Lausanne)
Yang Y, Xu S, Chen B, Chen S, Xu W, Lu L, Zhu X, Liao H, Tian J.   +8 more
europepmc   +1 more source