Results 91 to 100 of about 18,259,704 (253)

Person-centered pain management - science and art [PDF]

open access: yes, 2013
We are witnessing an unprecedented development of the medical science, which promises to revolutionize health care and improve patients' health outcomes. However, the core of the medical profession has always been and will be the relationship between the
Janjanin, Mladen   +2 more
core   +1 more source

Medical Ethics Education in Britain, 1963-1993 [PDF]

open access: yes, 2007
Annotated and edited transcript of a Witness Seminar held on 9 May 2006. Introduction by Professor Sir Kenneth Calman.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2007.©The Trustee of the Wellcome Trust, London, 2007 ...
Reynolds, LA, Tansey, EM
core   +3 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Dual Targeting of Inflammatory and Immune Checkpoint Pathways to Overcome Radiotherapy Resistance in Esophageal Squamous Cell Carcinoma

open access: yesJournal of Inflammation Research
Zhifeng Qu,1 Linlin Shi,2 Pei Wang,1 Anshun Zhao,2 Xuewei Zheng,3 Qinan Yin1,3 1Department of Radiation Oncology; Cancer Institute, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang ...
Qu Z   +5 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Neutrophil Extracellular Traps in Tumors and Potential Use of Traditional Herbal Medicine Formulations for Its Regulation

open access: yesInternational Journal of Nanomedicine
Xiang Li,1,* Lei Hu,1,* Abid Naeem,2,3,* Shanghua Xiao,2 Ming Yang,2 Hongming Shang,4 Jing Zhang1,2 1National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang,
Li X   +6 more
doaj  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Effects of a Novel Curcumin Derivative Loaded Long-Circulating Solid Lipid Nanoparticle on the MHCC-97H Liver Cancer Cells and Pharmacokinetic Behavior

open access: yesInternational Journal of Nanomedicine, 2022
Yumeng Wei,1– 3,* Ke Li,1– 3,* Wenmei Zhao,1– 3,* Yingmeng He,2,4 Hongping Shen,2,5 Jiyuan Yuan,2,5 Chao Pi,1– 3 Xiaomei Zhang,6 Mingtang Zeng,1– 3 Shaozhi Fu,7 Xinjie Song,8,9 Robert J Lee,10 Ling Zhao2,3 1Key Laboratory of Medical ...
Wei Y   +12 more
doaj  

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