Results 111 to 120 of about 18,259,704 (253)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Novel Insights into the Kallikrein–Kinin System in Fulminant Myocarditis: Physiological Basis and Potential Therapeutic Advances

Journal of Inflammation Research
Mengmeng Ji,1,* Xiao Ran,2,3,* Houjuan Zuo,1 Qin Zhang4 1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China ...
Ji M, Ran X, Zuo H, Zhang Q
doaj  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Mesenchymal Stem Cell-Derived Exosomes: A Tool for Heart Failure Repair — From Molecular Mechanisms to Clinical Potential

Journal of Inflammation Research
Ming-Tai Chen,1– 4,* Zhen-Xun Wan,5,* Yuan-Yuan Li,2,3,* Xiao-Lin Li,5 Yang Luo,5 Shi-Yun Yang,5 Hang Jiang,5 Qiu-Yu Liu,6 Rui Lyu,5 Yan Jiang,5 Gang Luo,5 Meng-Nan Liu51Faculty of Chinese Medicine and State Key Laboratory of ...
Chen MT, Wan ZX, Li YY, Li XL, Luo Y, Yang SY, Jiang H, Liu QY, Lyu R, Jiang Y, Luo G, Liu MN   +11 more
doaj  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Assessment of the quality of stored blood for transfusion at Mbarara Regional Referral Hospital, Southwestern Uganda

Journal of Blood Medicine, 2019
Hope Alice Mbabazi Rukundo,1 Ivan Mugisha Taremwa,2 Enoch Muwanguzi,3 Mark Ndyomubantu,4 Frederick Byarugaba,5 Bernard Natukunda31Department of Physiology, Faculty of Medicine, Mbarara University of Science and Technology (MUST), Mbarara, Uganda ...
Rukundo HAM, Taremwa IM, Muwanguzi E, Ndyomubantu M, Byarugaba F, Natukunda B   +5 more
doaj  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Barriers and Facilitators to Screening for Kidney Disease Among Older Adults with Hypertension and Diabetes in Mbarara Southwestern Uganda: Healthcare Providers’ Perspective

Journal of Multidisciplinary Healthcare
Judith Owokuhaisa,1 Catherine N Abaasa,2 Rose Muhindo,3 Pius Musinguzi,4 Godfrey Zari Rukundo5 1Faculty of Medicine, Department of Physiotherapy, Mbarara University of Science and Technology, Mbarara, Uganda; 2Faculty of Medicine, Department of Medical ...
Owokuhaisa J, Abaasa CN, Muhindo R, Musinguzi P, Rukundo GZ   +4 more
doaj  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source