Results 201 to 210 of about 18,259,704 (253)

Targeting Problems and Adhering to Standards: A Pathway to Uniform Clinical Laboratory Processes that Maximize the Benefits of Pharmacogenomics. [PDF]

Clin Pharmacol Ther
Fieg E, Kerman B, Berenbrok LA, Frear S, Marcath L, Massart M, Berman N.   +6 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Butylphthalide combined with tenecteplase in mild disabling acute ischaemic stroke in China (BENEFIT-2): study protocol for a multicentre, randomised, double-blind, active-controlled trial. [PDF]

BMJ Open
Tang Q, Wang L, Tang L, Wang D, Wang D, Li Y, Zhang X, Liu R, Wang S, Zeng Y, Shen M, Zhang L.   +11 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Correction: Cell cycle dysregulation: a central hub in colitis-associated colorectal carcinogenesis. [PDF]

Front Immunol
Fu Y, Wang Y, Wu S, Ying Y, Li J, Ou Y, Wang Y, Li L, Wu Y, Yan J, Yang Z.   +10 more
europepmc   +1 more source

[The Second Questionnaire Report of Safety Control on Instruments in a Nuclear Medicine Laboratory. Subcommittee of Nuclear Medicine Technology, Medical and Pharmaceutical Committee, Japan Radioisotope Association].

Radioisotopes, 1991
openaire   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Safeguarding the Right to a Whole Life. [PDF]

Cancer Innov
Qiao J, Ma F.
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Correction to: Formulation and evaluation of hydrogel based on Brazilian propolis ethanol extract for promoting diabetic wound healing. [PDF]

BMC Biotechnol
Huo H, Zhou Z, Guo R, Zhang J, Li M, Zeng H, Zhao D, Terekhov RP, Jiang P, Zhou Q, Li B.   +10 more
europepmc   +1 more source