Results 141 to 150 of about 6,229,843 (307)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Distribution and Genetic Characterization of the MNS Blood Group in Multi-Ethnic Populations of East China

Journal of Blood Medicine
Zihao Xu,1,* Zhihong Fang,2,* Rong Lu,1 Jia Jiang,1 Shuhong Xie,3 Mingyuan Wang,1 Yiming Jin,1 Zhen Liu1 1Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China; 2Department of Laboratory Medicine ...
Xu Z, Fang Z, Lu R, Jiang J, Xie S, Wang M, Jin Y, Liu Z   +7 more
doaj  

Extracting laboratory test information from paper-based reports. [PDF]

BMC Med Inform Decis Mak, 2023
Ma MW, Gao XS, Zhang ZY, Shang SY, Jin L, Liu PL, Lv F, Ni W, Han YC, Zong H.   +9 more
europepmc   +1 more source

Optical guidance vidicon test program [PDF]

A laboratory and field test program was conducted to quantify the optical navigation parameters of the Mariner vidicons. A scene simulator and a camera were designed and built for vidicon tests under a wide variety of conditions.
Eiseman, A. R., Stanton, R. H., Voge, C. C.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Comprehensive improvements in the emergency laboratory test process based on information technology. [PDF]

BMC Med Inform Decis Mak, 2023
Zhang L, Liu ZH, Lv YJ, Fu S, Luo ZM, Guo ML.   +5 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Professional role and hierarchy shape adherence to electronic alerts for laboratory test ordering. [PDF]

Sci Rep
Greco A, Garo ML, Zandonà M, Clivio L, Gabutti L.   +4 more
europepmc   +1 more source

Discounting in developing countries: a pilot experiment in Timor-Leste [PDF]

We conduct laboratory experiments in Timor-Leste designed to test if individual discount rates vary with the time horizon for which the rate is elicited.
Anabela Botelho, Elisabet E. Rutstrom, Glenn W. Harrison, Lígia Pinto, Paula Veiga   +4 more
core