Results 151 to 160 of about 8,970,804 (217)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Tractor Testing; Belt Power; Cockshut
, 1950 Cockshutt 40 tractor during belt test, test 442. The tractor is inside the tractor test lab, and the drive belt can clearly be seen.
Nebraska Tractor Test Laboratory
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Tractor Testing; Drawbar Testing; John Deere
, 1949 The John Deere MT tractor during the drawbar test, while towing the Adams test car and two load ...
Nebraska Tractor Test Laboratory
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Tractor Testing; Drawbar; Oliver
, 1947 Fuel drain at end of 10-hour test. Test no. 391 Oliver STD 88 HG. The amounts of fuel put in the empty tank at the start and during the test, as well as the amount of fuel drained from the tank determined the amount of fuel used and provided data for the
Nebraska Tractor Test Laboratory
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Tractor Testing; Drawbar; Caterpillar
, 1940 Caterpillar D8 during drawbar test. Front three-quarter view of Caterpillar D8 crawler towing the Adams test car and four other load tractors. The test car is offset to the right side from the main load, which could not be transmitted through its ...
Nebraska Tractor Test Laboratory
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Agnes Haag, the laboratory's secretary, measuring the latest drawbar test tracing from the recorder. She is operating a planimeter. The planimeter is used for determining the average drawbar pull on the test.
Nebraska Tractor Test Laboratory
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