Results 141 to 150 of about 173,668 (337)
ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, EarlyView.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
Avaliação e reabilitação vestibular no indivíduo idoso
Revista Brasileira de Geriatria e GerontologiaConsiderando a necessidade de propiciar melhora na qualidade de vida do idoso e a elevada incidência de queixas relacionadas aos transtornos de equilíbrio nessa faixa etária, este estudo teve como objetivo avaliar o equilíbrio estático e dinâmico de ...
Natália Daniela Rezende Mirallas +4 more
doaj +1 more source
Energy Efficiency of Software Transactional Memory in a Heterogeneous Architecture [PDF]
, 2016 Hardware vendors make an important effort creating low-power CPUs that keep battery duration and durability above acceptable levels. In order to achieve this goal and provide good performance-energy for a wide variety of applications, ARM designed the ...
Asenjo-Plaza, Rafael +5 more
core
Magneto‐X Effects in Magnetic Soft Materials and Their Applications
Advanced Science, EarlyView.This review systematically explores magnetic soft materials (MSMs), a novel class of composites that transform under magnetic fields. It catalogs fundamental “Magneto‐X” effects, classifies materials by their matrix and magnetic fillers, and highlights transformative applications in soft robotics, biomedical devices, flexible electronics, etc. Finally,
Ziyin Xiang +5 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo +9 more
wiley +1 more source
Rotordynamic coefficients for stepped labyrinth gas seals [PDF]
The basic equations are derived for compressible flow in a stepped labyrinth gas seal. The flow is assumed to be completely turbulent in the circumferential direction where the friction factor is determined by the Blasius relation.
Scharrer, Joseph K.
core +1 more source
Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance
Advanced Science, EarlyView.DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin +15 more
wiley +1 more source
Advanced Science, EarlyView.This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou +7 more
wiley +1 more source
Chinese Journal of Contemporary Neurology and NeurosurgeryObjective To investigate the correlation between vestibular symptoms and balance/ walking function in patients with acute brain stem infarction. Methods Fifty-one patients with acute brain stem infarction with a Functional Ambulation Category Scale ...
HUANG Mao‐juan +5 more
doaj +1 more source