Results 281 to 290 of about 152,483 (357)

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

open access: yesPediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu   +4 more
wiley   +1 more source

TREM2 Downregulation Disrupts Microglial Function and Synaptic Pruning Through RA/RARα Signaling: Mechanisms Underlying Autism‐Like Behaviors

open access: yesPediatric Discovery, EarlyView.
Downregulation of TREM2 induces autism‐like behaviors in healthy rats by impairing microglial function and triggering aberrant synaptic pruning. RA/RARα signaling pathway modulates alterations in TREM2 expression. Serum sTREM2 levels correspond to alterations in brain TREM2 expression.
Min Lu   +9 more
wiley   +1 more source

Maternal α-cypermethrin and permethrin exert differential effects on fetal growth, placental morphology, and fetal neurodevelopment in mice. [PDF]

open access: yesToxicol Sci
Elser BA   +10 more
europepmc   +1 more source

Docosahexaenoic acid ameliorates autistic‐like behaviors by inhibiting oxidative stress and inflammatory response in neonatal maternal separation rats

open access: yesPediatric Discovery, EarlyView.
The JNK pathway and oxidative stress are activated, and pro‐inflammatory cytokines are increased in neonatal maternal separation (NMS) rats. While docosahexaenoic acid treatment suppresses the activation of JNK pathway and oxidative stress, and reduces pro‐inflammatory cytokines release, thereby improving autism‐like behavior induced by NMS.
Boqing Xu   +5 more
wiley   +1 more source

Flowering out of sync: Climate change alters the reproductive phenology of Terminalia paniculata in the Western Ghats of India

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
Understanding how climate change impacts the plant life cycle is critical for maintaining biodiversity and ecosystem services. Our findings suggest that Terminalia paniculata Roth, a common tropical deciduous tree species in the Western Ghats, is now flowering and fruiting at more scattered times than it used to in the past.
Ananthapadmanaban Karthikeyan   +2 more
wiley   +1 more source

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