Results 151 to 160 of about 36,597 (195)
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Journal of Molecular Biology, 2013
The ability to regulate gene expression is essential for controlling metabolic events in a cell. Proteins that function like molecular switches respond to fluctuations in the environment to maintain homeostasis. The operon model, proposed by Jacob and Monod, provides a cogent depiction for how gene expression is regulated. A molecular mechanism for the
Rob Phillips
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The ability to regulate gene expression is essential for controlling metabolic events in a cell. Proteins that function like molecular switches respond to fluctuations in the environment to maintain homeostasis. The operon model, proposed by Jacob and Monod, provides a cogent depiction for how gene expression is regulated. A molecular mechanism for the
Rob Phillips
exaly +3 more sources
Isolation of Pure lac Operon DNA*
Nature, 1969Two specialized transducing phages, which carry the lac operon of Escherichia coli inserted into their DNA in opposite orientations, are used as a source of complementary sequences from which to prepare pure lac operon duplex. The availability of a single pure promoter will facilitate many new experiments on genetic transcription.
Jon Beckwith
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Catabolite Sensitive Site of the lac Operon
Nature, 1969A partial deletion in the lac p region makes the lac operon insensitive to catabolite repression.
A E, Silverstone +4 more
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Modeling Gene Expression: Lac operon
2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2021Gene regulation is an essential process for cell development, having a profound effect in dictating cell functions. Bacterial genes are often regulated through inducible systems like the Lac operon which plays an important role in cell metabolism. An accurate model of its regulation can reveal the dynamics of gene expression.
Sarai Velazco +6 more
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2021
The lac operon regulatory mechanism allows bacteria to sense external nutrient conditions and, accordingly, regulate gene transcription that assists in the digestion of available nutrients. The lac system produces a switch-like dynamic behavior, where the switching between ‘on’ and ‘off’ states of lac gene transcription depends on the specific ...
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The lac operon regulatory mechanism allows bacteria to sense external nutrient conditions and, accordingly, regulate gene transcription that assists in the digestion of available nutrients. The lac system produces a switch-like dynamic behavior, where the switching between ‘on’ and ‘off’ states of lac gene transcription depends on the specific ...
openaire +1 more source
Transient Repression of the lac Operon
Journal of Bacteriology, 1967Severe transient repression of constitutive or induced β-galactosidase synthesis occurs upon the addition of glucose to cells of Escherichia coli growing on glycerol, succinic acid, or lactic acid. Only mutants particularily well adapted to growth on glucose exhibit this phenomenon when transferred to a glucose ...
B, Tyler, W F, Loomis, B, Magasanik
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Studies on the in vitro transcription and translation of the lac operon
Archives of Biochemistry and Biophysics, 1974With the use of rifampicin to stop the initiation of RNA synthesis, the in vitro synthesis of β -galactosidase has been carried out in two separate stages, transcription and translation. In this system it has been possible to examine whether substances, which affect the synthesis of the enzyme, function at the transcription or translation level of ...
H F, Kung +4 more
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Genetic mapping of a new promoter for the lac operon
Journal of Molecular Biology, 1975Abstract A mutation (or group of mutations) necessary for the synthesis of increased quantities of lac mRNA has been localized within the structural gene for the lac repressor ( lacI ). This mutation is probably a new cyclic AMP-binding protein-dependent promoter within the I gene.
J, Bruenn, P, Le Lucia-Curtin
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2017
The lac operon is a classic model system for bacterial gene regulation, and has been studied extensively in E. coli, a classic model organism. However, not much is known about E. coli’s ecology and life outside the laboratory, in particular in soil and water environments.
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The lac operon is a classic model system for bacterial gene regulation, and has been studied extensively in E. coli, a classic model organism. However, not much is known about E. coli’s ecology and life outside the laboratory, in particular in soil and water environments.
openaire +1 more source
Dynamics and bistability in a reduced model of the lac operon
Chaos: An Interdisciplinary Journal of Nonlinear Science, 2004It is known that the lac operon regulatory pathway is capable of showing bistable behavior. This is an important complex feature, arising from the nonlinearity of the involved mechanisms, which is essential to understand the dynamic behavior of this molecular regulatory system.
Yildirim, Necmettin +3 more
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