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Human Lacrimal Gland Gene Expression. [PDF]

PLoS ONE, 2017
The study of human lacrimal gland biology and development is limited. Lacrimal gland tissue is damaged or poorly functional in a number of disease states including dry eye disease.
Vinay Kumar Aakalu, Sowmya Parameswaran, Mark Maienschein-Cline, Neil Bahroos, Dhara Shah, Marwan Ali, Subramanian Krishnakumar   +6 more
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Ocular manifestations and immunological profiles of thyroid eye disease with lacrimal gland enlargement [PDF]

Frontiers in Endocrinology
IntroductionThyroid eye disease (TED) is a prevalent autoimmune inflammatory condition in patients diagnosed with Graves’ disease (GD). The lacrimal glands are implicated as an additional target organ of autoimmune reactions in TED, alongside orbital ...
Yan Sun, Fan Shi, Congyao Wang, Xia Dong, Yihua Su, Fenfen Yu, Shubin Hong, Dide Wu, Mengsha Zou, Zhiyun Yang, Haipeng Xiao, Pengxia Wan   +11 more
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Yiguanjian alleviates ocular surface inflammation and lacrimal gland immune dysregulation in experimental dry eye disease: evidence from in vivo and in vitro models [PDF]

Frontiers in Medicine
BackgroundPersistent ocular surface inflammation and lacrimal gland immune dysregulation are central to the progression of dry eye disease (DED). Th17/Treg imbalance contributes to sustained inflammatory activation in the ocular surface and lacrimal ...
Yuan Zhong, Yuan Zhong, Jian Shi, Xiyuan Liu, Xiyuan Liu, Yanwen Zhang, Qinghua Peng, Jun Peng, Jun Peng   +8 more
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Atypical imaging characteristics in patients with epithelial tumors of lacrimal gland and impact on initial surgical planning [PDF]

Frontiers in Oncology
PrecisApproximately one-quarter of lacrimal gland masses present with imaging findings not consistent with standard teaching for benign vs. malignant; it is prudent to do gross total resection in such cases if eye-sparing surgery is possible ...
Bita Esmaeli, Bita Esmaeli, Bita Esmaeli, Bita Esmaeli, Tracy Lu, Leena Ketonen, James Matthew Debnam   +6 more
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The Value of the High-frequency Ultrasound System in Lacrimal Gland Prolapse Treatment [PDF]

Plastic and Reconstructive Surgery, Global Open
Background:. This study aimed to evaluate the efficacy of high-frequency ultrasound in the preoperative diagnosis of lacrimal gland prolapse to aid surgical planning, minimize complications, and enhance patient satisfaction. Methods:.
Guang Zhang, MD, Yuzhi Qiu, MD, Tianyi Gu, MD, Yuna Luo, MD, Mengle Yan, MD, Yongqian Wang, MD, Hongli Chai, MD, Jianjian Lu, MD   +7 more
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Sleep deprivation disrupts lacrimal gland homeostasis via hypothalamic-pituitary-adrenal axis and gut dysbiosis in mice [PDF]

Communications Biology
Sleep deprivation (SD) disrupts systemic homeostasis, but how it drives ocular surface disease remains unclear. Using a male mouse SD model, we show that chronic SD activates the hypothalamic-pituitary-adrenal (HPA) axis, elevates corticosterone, alters ...
Shenzhen Huang, Shufan Yu, Wenxiao Zhang, Di Qi, Xiaoting Pei, Dingli Lu, Mengru Ba, Shuting Xuan, Duliurui Huang, Jingwen Yang, Zhijie Li   +10 more
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Development of lacrimal gland organoids from iPSC derived multizonal ocular cells

Frontiers in Cell and Developmental Biology, 2023
Lacrimal gland plays a vital role in maintaining the health and function of the ocular surface. Dysfunction of the gland leads to disruption of ocular surface homeostasis and can lead to severe outcomes.
Melis Asal, Melis Asal, Gamze Koçak, Gamze Koçak, Vedat Sarı, Vedat Sarı, Tuba Reçber, Emirhan Nemutlu, Canan Aslı Utine, Canan Aslı Utine, Sinan Güven, Sinan Güven, Sinan Güven   +12 more
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Advances in clinical examination of lacrimal gland

Frontiers in Medicine, 2023
In humans, the lacrimal gland is located in the socket of the frontal bone above the outer orbital area. As an essential part of the eye surface, the gland is fixed to the orbital periosteum by connective tissue.
Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Yujie Zhang, Yujie Zhang, Yujie Zhang, Yujie Zhang, Ke Shi, Ke Shi, Ke Shi, Ke Shi, Huping Wu, Huping Wu, Huping Wu, Huping Wu, Shangkun Ou, Shangkun Ou, Shangkun Ou, Shangkun Ou, Shangkun Ou   +20 more
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Morphometric and volumetric analysis of lacrimal glands in patients with thyroid eye disease

Scientific Reports, 2023
Assessment of morphometric and volumetric changes in lacrimal glands in thyroid eye disease, its clinical manifestations in relation of disease progression.
Ana Starčević, Zoran Radojičić, Aleksandra Djurić Stefanović, Aleksandar Trivić, Ivan Milić, Marina Milić, Dragan Matić, Jovana Andrejic, Vuk Djulejic, Igor Djoric   +9 more
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Association of the macrophage migration inhibitory factor promoter polymorphisms with benign lymphoepithelial lesion of lacrimal gland [PDF]

International Journal of Ophthalmology, 2017
AIM: To identify the association of the macrophage migration inhibitory factor (MIF) gene polymorphism with the susceptibility of benign lymphoepithelial lesions (BLEL) of the lacrimal gland.
Qin-Jian Li, Peng-Xiang Zhao, Xu-Juan Zhang, Yang Yi, Dan-Ying Cheng, Jian-Min Ma, Xue-Mei Ma   +6 more
doaj   +1 more source