Results 191 to 200 of about 326,261 (230)

The evolutionary tale of lactase persistence in humans

Nature Reviews Genetics, 2023
Luis B Barreiro
semanticscholar   +3 more sources

DNA polymorphisms associated with lactase persistence, self‐perceived symptoms of lactose intolerance, milk and dairy consumption, and ancestry, in the Uruguayan population

American Journal of Human Biology, 2023
Uruguay has one of the highest per capita milk intakes worldwide, even with a limited supply of lactose‐free products; furthermore, the admixed nature of its population is well known, and various frequencies of lactase persistence (LP) are observed in ...
Raúl Germán Negro Gaudin, G. Figueiro, Sara Flores-Gutiérrez, Patricia Mut, Yasser Vega-Requena, Lorena Luna-Andrada, E. Ackermann, P. Hidalgo, Á. Carracedo, M. Torres, M. Sans   +10 more
semanticscholar   +1 more source

Crisis and chronic selection of lactase persistence

Nature Food, 2022
Anne Mullen
semanticscholar   +2 more sources

White as milk: Biocentric bias in the framing of lactose intolerance and lactase persistence.

Sociology of Health and Illness, 2022
The majority of the world population is lactose intolerant, as 65%-70% of people lose the enzymes to digest lactose after infancy. Yet, in the United States, where lactose intolerance is predicted to affect only 36% of people, this phenomenon is often ...
Eli J. Kaufman, Catherine D Tan
semanticscholar   +1 more source

Lactose digestion and the evolutionary genetics of lactase persistence

Human Genetics, 2008
It has been known for some 40 years that lactase production persists into adult life in some people but not in others. However, the mechanism and evolutionary significance of this variation have proved more elusive, and continue to excite the interest of investigators from different disciplines.
Yuval Itan, Mark G Thomas, Dallas M Swallow   +2 more
exaly   +4 more sources

Human lactase and the molecular basis of lactase persistence

Biochemical Genetics, 1985
Human lactase purified from detergent extracts of the total membrane fraction of postmortem jejunum by means of monoclonal immunoadsorbent chromatography appears to be a dimer of subunits identical in Mr (160K). Trypsin or papain removes a small hydrophobic anchoring peptide from each subunit to give a hydrophilic enzyme which no longer interacts with ...
Anna J. Furth, B. Griffiths, Mae-Wan Ho, Hilary Bolton, Jennifer Potter, Dallas M. Swallow   +5 more
openaire   +3 more sources

Evolution of lactase persistence: an example of human niche construction [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2011
Niche construction is the process by which organisms construct important components of their local environment in ways that introduce novel selection pressures. Lactase persistence is one of the clearest examples of niche construction in humans. Lactase is the enzyme responsible for the digestion of the milk sugar lactose and its production decreases ...
Yuval Itan, Mathias Currat, Dallas M Swallow   +2 more
exaly   +4 more sources

Convergent adaptation of human lactase persistence in Africa and Europe [PDF]

Nature Genetics, 2006
A SNP in the gene encoding lactase (LCT) (C/T-13910) is associated with the ability to digest milk as adults (lactase persistence) in Europeans, but the genetic basis of lactase persistence in Africans was previously unknown. We conducted a genotype-phenotype association study in 470 Tanzanians, Kenyans and Sudanese and identified three SNPs (G/C-14010,
Sarah A Tishkoff, Floyd A Reed, Benjamin F Voight   +2 more
exaly   +5 more sources

Lactase Non-persistence and Lactose Intolerance

Current Gastroenterology Reports, 2017
To evaluate the clinical and nutritional significance of genetically determined lactase non-persistence and potential lactose and milk intolerance in 65-70% of the world's adult population.Milk consumption is decreasing in the USA and is the lowest in countries with a high prevalence of lactase non-persistence.
David M. Paige, Theodore M. Bayless, Elizabeth G Brown   +2 more
exaly   +4 more sources

The -13914G>A variant upstream of the lactase gene (LCT) is associated with lactase persistence/non-persistence

Scandinavian Journal of Clinical and Laboratory Investigation, 2010
Adult-type hypolactasia (lactase non-persistence) is a common cause of gastrointestinal symptoms. Several DNA sequence variants have been identified for the lactase-persistence/non-persistence (LP/LNP), the most common being the C to T residing -13910 bp upstream of the lactase gene (LCT).
Suvi Torniainen, Yulia Khabarova, Irma Järvelä, Mauri Isokoski, Erkki Savilahti, Kari Mattila   +5 more
openaire   +3 more sources