Results 201 to 210 of about 326,261 (230)

The Role of Lactase Persistence in Precolonial Development [PDF]

SSRN Electronic Journal, 2012
This paper argues that a genetic adaptation to the Neolithic Revolution led to differential levels of development in the precolonial era. The ability to digest milk, or to be lactase persistent, is conferred by a gene variant that is unequally distributed across the Old World.
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Epigenetics and Epidemiology of Lactase Persistence

International Journal of High School Research
:In adult mammals, the inability to digest lactose due to lactase non-persistence or adult-type hypolactasia, is relatively common after the weaning stage.
Hannah Feng
semanticscholar   +1 more source

Testing for lactase non-persistence in a Dutch population: Genotyping versus the hydrogen breath test

Annals of Clinical Biochemistry, 2023
Background Lactose intolerance is defined as the presence of gastrointestinal symptoms, such as bloating, abdominal pain or diarrhoea, after consumption of lactose in individuals with lactose malabsorption. Most cases involve primary lactose intolerance,
K. Stouten, F. Wolfhagen, Rob Castel, M. van de Werken, Johan Klerks, F. Verheijen, H. J. Vermeer   +6 more
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Microsatellite variation and evolution of human lactase persistence

Human Genetics, 2005
The levels of haplotype diversity within the lineages defined by two single-nucleotide polymorphisms (SNPs) (-13910 C/T and -22018 G/A) associated with human lactase persistence were assessed with four fast-evolving microsatellite loci in 794 chromosomes from Portugal, Italy, Fulbe from Cameroon, São Tomé and Mozambique.
Coelho M., LUISELLI, DONATA, Bertorelle G., Lopes A. I., Seixas S., Destro Bisol G., Rocha J.   +6 more
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Genetics of Lactase Persistence and Lactose Intolerance

Annual Review of Genetics, 2003
▪ Abstract  The enzyme lactase that is located in the villus enterocytes of the small intestine is responsible for digestion of lactose in milk. Lactase activity is high and vital during infancy, but in most mammals, including most humans, lactase activity declines after the weaning phase.
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Lactase non-persistent genotype distribution in Italy

Minerva Gastroenterology, 2017
Adult-type hypolactasia is a frequent condition of lactose malabsorption; in Europe the distribution of adult-type hypolactasia have been shown to display a North-South gradient. Genotyping for LCT-13910 C>T polymorphism has been proposed as a useful diagnostic marker of adult-type hypolactasia.
Savina Dipresa, Annalisa Pediroda, Cristina Zadro, Giovanni Zorzetti, Francesco Menegoni   +4 more
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Genomic Data from an Ancient European Battlefield Indicates On-Going Strong Selection on a Genomic Region Associated with Lactase Persistence Over the Last 3,000 Years

Social Science Research Network, 2020
Lactase persistence (LP), the continued expression of lactase into adulthood, is the most strongly selected single gene trait over the last 10,000 years in multiple human populations. It has been posited that the primary allele causing LP among Eurasians,
J. Burger, Vivian Link, J. Blöcher, Anna Schulz, Christian Sell, Zoé Pochon, Y. Diekmann, A. Žegarac, Zuzana Hofmanová, L. Winkelbach, Carlos S. Reyna-Blanco, Vanessa C. Bieker, Jörg Orschiedt, Ute Brinker, Amelie Scheu, R. Bollongino, Gundula Lidke, S. Stefanović, Detlef Jantzen, E. Kaiser, T. Terberger, Mark George Thomas, K. Veeramah, Daniel Wegmann   +23 more
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Persistence of high intestinal lactase activity in Pakistan

Human Genetics, 1983
In order to determine the incidence of persistence of high intestinal lactase activity (PLA) in a Pakistani human population, 53 probands belonging to the Punjabi ethnic group were examined using a lactose tolerance test. The incidence of PLA in the sample was found to be 55%, which has been compared with the incidence in other ethnic groups racially ...
Mahmud Ahmad, Hassan Abbas
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Lactase Persistence in Central Asia: Phenotype, Genotype, and Evolution

Human Biology, 2011
The aim of the present study is to document the evolution of the lactase persistence trait in Central Asia, a geographical area that is thought to have been a region of long-term pastoralism. Several ethnic groups co-exist in this area: Indo-Iranian speakers who are traditionally agriculturist (Tajik) and Turkic speakers who used to be nomadic herders (
Patrick Pasquet, Evelyne Heyer, Lionel Brazier, Lluis Quintana-Murci, Laure Ségurel, Laure Ségurel, Frédéric Austerlitz, Frédéric Austerlitz, Tatiana Hegay, Michel Veuille, Myriam Georges   +10 more
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The lactase persistence/non-persistence polymorphism is controlled by a cis-acting element

Human Molecular Genetics, 1995
Lactase activity is present at high levels in the small intestine of some human adults and not others. This is due to a genetically determined polymorphism which affects the developmental regulation of the expression of the lactase gene. This polymorphism is of considerable interest in relation to cultural differences in nutrition but despite ...
V R Sams, Wendy S. Pratt, M. Sarner, Mauro Rossi, Yangxi Wang, C. B. Harvey, Dallas M. Swallow, Salvatore Auricchio   +7 more
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