Results 201 to 210 of about 334,943 (248)

White as milk: Biocentric bias in the framing of lactose intolerance and lactase persistence.

Sociology of Health and Illness, 2022
The majority of the world population is lactose intolerant, as 65%-70% of people lose the enzymes to digest lactose after infancy. Yet, in the United States, where lactose intolerance is predicted to affect only 36% of people, this phenomenon is often ...
Eli J. Kaufman, Catherine D Tan
semanticscholar   +1 more source

Human lactase and the molecular basis of lactase persistence

Biochemical Genetics, 1985
Human lactase purified from detergent extracts of the total membrane fraction of postmortem jejunum by means of monoclonal immunoadsorbent chromatography appears to be a dimer of subunits identical in Mr (160K). Trypsin or papain removes a small hydrophobic anchoring peptide from each subunit to give a hydrophilic enzyme which no longer interacts with ...
J, Potter, M W, Ho, H, Bolton, A J, Furth, D M, Swallow, B, Griffiths   +5 more
openaire   +2 more sources

Lactase Non-persistence and Lactose Intolerance

Current Gastroenterology Reports, 2017
To evaluate the clinical and nutritional significance of genetically determined lactase non-persistence and potential lactose and milk intolerance in 65-70% of the world's adult population.Milk consumption is decreasing in the USA and is the lowest in countries with a high prevalence of lactase non-persistence.
Theodore M, Bayless, Elizabeth, Brown, David M, Paige   +2 more
exaly   +3 more sources

Lactose digestion and the evolutionary genetics of lactase persistence

Human Genetics, 2008
It has been known for some 40 years that lactase production persists into adult life in some people but not in others. However, the mechanism and evolutionary significance of this variation have proved more elusive, and continue to excite the interest of investigators from different disciplines.
Yuval Itan, Mark G Thomas, Dallas M Swallow   +2 more
exaly   +3 more sources

Evolution of lactase persistence: an example of human niche construction [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2011
Niche construction is the process by which organisms construct important components of their local environment in ways that introduce novel selection pressures. Lactase persistence is one of the clearest examples of niche construction in humans. Lactase is the enzyme responsible for the digestion of the milk sugar lactose and its production decreases ...
Yuval Itan, Mathias Currat, Dallas M Swallow   +2 more
exaly   +5 more sources

Lactase non-persistent genotype distribution in Italy

Minerva Gastroenterology, 2017
Adult-type hypolactasia is a frequent condition of lactose malabsorption; in Europe the distribution of adult-type hypolactasia have been shown to display a North-South gradient. Genotyping for LCT-13910 C>T polymorphism has been proposed as a useful diagnostic marker of adult-type hypolactasia.
Cristina, Zadro, Savina, Dipresa, Giovanni, Zorzetti, Annalisa, Pediroda, Francesco, Menegoni   +4 more
openaire   +2 more sources

Association of lactose intake and lactase persistence genotype with microbial taxa and function in healthy multi-ethnic U.S. adults.

Food & Function
Lactase persistence is a genetically inherited trait that enables continued lactose digestion into adulthood. Lactase non-persistence (LNP) individuals often experience incomplete lactose digestion, allowing undigested lactose to reach the colon, where ...
Yirui Tang, Andrew Oliver, Zeynep Alkan, Ian Korf, Liping Huang, Mary E. Kable, Danielle G. Lemay   +6 more
semanticscholar   +1 more source

Revisiting the Evolution of Lactase Persistence: Insights from South Asian Genomes

bioRxiv
Lactase persistence (LP), the ability to digest lactose from milk into adulthood, is a classic example of natural selection in humans. Multiple mutations upstream of the LCT gene are associated with LP and have been previously shown to be under selection
Elise Kerdoncuff, Meaghan Marohn, Nathan Cramer, Sharmistha Dey, Sharon L. R. Kardia, K. Thangaraj, Laure Ségurel, Jinkook Lee, A. Dey, Priya Moorjani   +9 more
semanticscholar   +1 more source

Microsatellite variation and evolution of human lactase persistence

Human Genetics, 2005
The levels of haplotype diversity within the lineages defined by two single-nucleotide polymorphisms (SNPs) (-13910 C/T and -22018 G/A) associated with human lactase persistence were assessed with four fast-evolving microsatellite loci in 794 chromosomes from Portugal, Italy, Fulbe from Cameroon, São Tomé and Mozambique.
Coelho M., LUISELLI, DONATA, Bertorelle G., Lopes A. I., Seixas S., Destro Bisol G., Rocha J.   +6 more
openaire   +3 more sources

Effects of ancestry, agriculture, and lactase persistence on the stature of prehistoric Europeans

bioRxiv
Ancient DNA has revolutionized our understanding of human evolutionary history, but studies focusing solely on genetic variation tell an incomplete story by neglecting phenotypic outcomes.
Samantha L. Cox, Kaeli Kaymak-Loveless, Carson Shin, Timka Alihodžić, K. W. Alt, Nadezhda Atanassova, Dider Binder, Morana Čaušević-Bully, Alexander Chohadzhiev, Stefan Chokhadzhiev, Henri Duday, B. Gaydarska, Anahit Khudaverdyan, Rafael Micó Pérez, N. Nicklisch, M. Novak, Camila Oliart Caravatti, Hélène Réveillas, Maïté Rivollat, Stéphane Rottier, Domagoj Tončinić, Steve Zaüner, I. Mathieson   +22 more
semanticscholar   +1 more source