Results 211 to 220 of about 334,943 (248)

The -13914G>A variant upstream of the lactase gene (LCT) is associated with lactase persistence/non-persistence

Scandinavian Journal of Clinical and Laboratory Investigation, 2010
Adult-type hypolactasia (lactase non-persistence) is a common cause of gastrointestinal symptoms. Several DNA sequence variants have been identified for the lactase-persistence/non-persistence (LP/LNP), the most common being the C to T residing -13910 bp upstream of the lactase gene (LCT).
Yulia, Khabarova, Suvi, Torniainen, Erkki, Savilahti, Mauri, Isokoski, Kari, Mattila, Irma, Järvelä   +5 more
openaire   +2 more sources

Persistence of high intestinal lactase activity in Pakistan

Human Genetics, 1983
In order to determine the incidence of persistence of high intestinal lactase activity (PLA) in a Pakistani human population, 53 probands belonging to the Punjabi ethnic group were examined using a lactose tolerance test. The incidence of PLA in the sample was found to be 55%, which has been compared with the incidence in other ethnic groups racially ...
H, Abbas, M, Ahmad
openaire   +2 more sources

Distinct Clinical Phenotypes in Lactase Non-Persistence: Symptomatic, Asymptomatic, and Gassy-Asymptomatic.

American Journal of Gastroenterology
INTRODUCTION Lactase deficiency allows undigested lactose to reach the colon, where fermentation triggers gastrointestinal symptoms. Although lactase persistence (LP) versus non-persistence (LNP) is genetically defined, many LNP individuals are symptoms ...
Michal Azimov, Ida Cohen-Michnik, Moshe Rottenstreich, Lior Katz, H. Zeigerman, Avihu H. Yona   +5 more
semanticscholar   +1 more source

Genetics of Lactase Persistence and Lactose Intolerance

Annual Review of Genetics, 2003
▪ Abstract  The enzyme lactase that is located in the villus enterocytes of the small intestine is responsible for digestion of lactose in milk. Lactase activity is high and vital during infancy, but in most mammals, including most humans, lactase activity declines after the weaning phase.
openaire   +2 more sources

LACTASE NON-PERSISTENCE AND CONSUMPTION OF DAIRY PRODUCTS AMONG THE TAJIK POPULATION LIVES IN SOUTHERN UZBEKISTAN.

International journal of scientific research
Aim: To determine the relationship between C/C-13910 genotyping and consumption of dairy products in a Tajik population and to study the incidence of gastrointestinal symptoms for dairy products in the LNP C/C-13910 carriers.
S. Kasimov
semanticscholar   +1 more source

The Role of Lactase Persistence in Precolonial Development

SSRN Electronic Journal, 2012
This paper argues that a genetic adaptation to the Neolithic Revolution led to differential levels of development in the precolonial era. The ability to digest milk, or to be lactase persistent, is conferred by a gene variant that is unequally distributed across the Old World.
openaire   +1 more source

Lactase Persistence in Central Asia: Phenotype, Genotype, and Evolution

Human Biology, 2011
The aim of the present study is to document the evolution of the lactase persistence trait in Central Asia, a geographical area that is thought to have been a region of long-term pastoralism. Several ethnic groups co-exist in this area: Indo-Iranian speakers who are traditionally agriculturist (Tajik) and Turkic speakers who used to be nomadic herders (
Heyer, Evelyne, Brazier, Lionel, Ségurel, Laure, Hegay, Tatiana, Austerlitz, Frédéric, Quintana-Murci, Lluis, Georges, Myriam, Pasquet, Patrick, Veuille, Michel   +8 more
openaire   +3 more sources

Molecular diagnosis of adult‐type hypolactasia (lactase non‐persistence)

Scandinavian Journal of Clinical and Laboratory Investigation, 2005
Adult‐type hypolactasia (lactase non‐persistence) is prevalent in most human populations preventing the digestion of lactose, the main sugar of milk, in adults 1.
openaire   +2 more sources

Hypolactasia and Lactase Persistence Historical Review and the Terminology

Scandinavian Journal of Gastroenterology, 1994
Lactase (more precisely lactase-phlorizin hydrolase) is located in the brush border of the small intestinal enterocytes and is responsible for the hydrolysis of dietary lactose. The earliest studies on lactase activity in mammals were published around the turn of the century.
openaire   +2 more sources

EVOLUTION OF LACTASE PERSISTENCE

The Lancet, 1989
S F, Hoegerman, R A, Schenck
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