Results 241 to 250 of about 553,288 (303)

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Toward implementation of lactate compared with pH in fetal scalp blood sampling during labor: A clinical comparative single-center study. [PDF]

Acta Obstet Gynecol Scand
van Woudenberg SJ, Mijnheer I, van Borren MMGJ, Roovers L, Janse F.   +4 more
europepmc   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

A systematic approach to MR spectroscopy of the brain: Indications, protocol, metabolites, and spectral analysis in neurologic diseases. [PDF]

Neuroradiol J
Rahman SM, Peng A, Si K, Kenny-Howell CL, Singh M, Asif MA, Rahman SZ, Rahmani S, Pasquini L, Adin M, Schrickel E, Tu LH.   +11 more
europepmc   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Lactate and lactylation in sepsis: regulation of immune-metabolic crosstalk and organ injury. [PDF]

Front Immunol
Li Z, Gu WJ, Li T, Dai X, Duan XJ, Yang F, Yin HY, Zhang Z, Li P.   +8 more
europepmc   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Consumption of Fructose by Cultured Primary Rat Astrocytes. [PDF]

Neurochem Res
Mesa-Leal M, Dringen R.
europepmc   +1 more source

Carbon starvation enhances microbiologically influenced corrosion in marine offshore infrastructures. [PDF]

Front Microbiol
Taghavi Kalajahi S, Lisec J, Ghafoori E, Salta M, Lund Skovhus T, Koerdt A.   +5 more
europepmc   +1 more source

Association of cerebral microdialysis monitoring with clinical outcomes after traumatic brain injury; A systematic review. [PDF]

Brain Spine
Rehber C, Turella S, Peul WC, Helbok R, van Essen TA, van Dijck JTJM, SOPRANI Collaborators.   +6 more
europepmc   +1 more source