Results 171 to 180 of about 355,547 (302)

The characteristics of collagen‐induced rheumatoid arthritis in macaques and the changes of heart

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The disease progression in CIA macaques was categorized into three stages: IIR (days 14–34): The indicators related to rheumatoid arthritis and the levels of immunoglobulin were all elevated. There was a small amount of joint effusion, edema and mild synovial hyperplasia. No joint swelling was observed by naked eye.
Lei Zhang   +8 more
wiley   +1 more source

Inhibition Profiling of <i>Rhodiola crenulata</i> on Lactate Dehydrogenase Isoenzymes. [PDF]

open access: yesMolecules
Wei YX   +7 more
europepmc   +1 more source

Blood Lactate as a Prognostic Biomarker for Survival and Weight Loss in Amyotrophic Lateral Sclerosis: An Exploratory–Validation Study

open access: yesAnnals of Neurology, EarlyView.
Objective Lactate is increasingly recognized as an energy substrate, but its relevance to amyotrophic lateral sclerosis (ALS) remains unclear. We examined whether blood lactate is associated with survival and weight loss in ALS. Methods This retrospective study included an Australian exploratory cohort and a Japanese validation cohort with clinical ...
Ryutaro Nakamura   +8 more
wiley   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

open access: yesAdvanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura   +14 more
wiley   +1 more source

High‐Altitude Hypoxemia in Adults With Sickle Cell Disease (SCD)

open access: yes
American Journal of Hematology, EarlyView.
Mofiyin A. Obadina   +4 more
wiley   +1 more source

Polyfluoroalkyl‐Tagged Cell‐Penetrating Peptide‐Additives Enhance Intracellular Protein Delivery via Sustained Monomeric Lipid Interaction

open access: yesAngewandte Chemie International Edition, EarlyView.
We introduce cell‐penetrating peptides (CPPs) with polyfluoroalkyl‐tags that drastically enhance intracellular protein delivery by promoting membrane retention. Via the combination of live‐cell imaging, biophysical analysis, and computational simulations, we reveal how fluorous CPPs interact with membranes via monomeric interactions and dynamic tag ...
Sarah Hansen   +10 more
wiley   +1 more source

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