Results 271 to 280 of about 344,963 (356)

Metabolic alterations in human pulmonary artery smooth muscle cells treated with PDGF‐BB

Animal Models and Experimental Medicine, EarlyView.
Metabolic abnormalities are considered to play a key regulatory role in vascular remodeling of pulmonary arterial hypertension. We analyzed the metabolome in the culture supernatants of human pulmonary artery smooth muscle cells (PASMC) during the malignant proliferation phenotype transition via a targeted metabolomics method. Significant and extensive
Meng‐Jie Zhang, Jie‐Jian Kou, Hong‐Da Zhang, Xin‐Mei Xie, Yun‐Feng Zhou, Ping Yuan, Xiao‐Bin Pang, Lu‐Ling Zhao, Jing Qiu, Yang‐Yang He   +9 more
wiley   +1 more source

Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors

Angewandte Chemie, EarlyView.
Our study introduces TL‐alkyne as an innovative tool for bio‐orthogonal labeling of endogenous XPB in live cells, facilitating the creation of a cell‐based imaging HCS assay. This platform not only enabled the identification of pelitinib as a novel XPB inhibitor but also demonstrated its potential to improve cancer treatment through synergistic effects
Shuqi Li, Hong‐Rui Zhang, Yang Yang, Ben Chi‐Bun Ko, Jin Shang, Haijun Guo, Dan Yang, Mankin Wong, Ricky Wing‐Cheung Chan, Karen Ka‐Yan Kung, Qian Zhao   +10 more
wiley   +2 more sources

Potential Mechanisms of Lactate Dehydrogenase and Bovine Serum Albumin Proteins as Antioxidants: A Mixed Experimental-Computational Study. [PDF]

Biochem Res Int
Ye J, Bounds A, Crumpton M, Long M, McDonough H, Srikhirisawan I, Gao S.   +6 more
europepmc   +1 more source

Rapid severe hypertension and organ damage in two‐kidney two‐clip rats produced by different sizes of clips

Animal Models and Experimental Medicine, EarlyView.
Blood pressure increases immediately when the 2K2C rats (made with 0.3, 0.25, and 0.2 mm U‐shaped clips) regain consciousness from anesthesia. 100% of the rats develop hypertension on the day of 2K2C surgery. Blood pressure continues to rise, resulting in severe hypertension and organ damage to the brain, heart, aorta, and kidneys at 1, 2, 4, and 6 ...
Jia‐Sheng Tian, Qi‐Sheng Ling, Yu‐Chen Wei, Dao‐Xin Wang, Chao‐Yu Miao   +4 more
wiley   +1 more source

Communicative Nanomotors Reprogram Cancer Cell Death via Pyroptosis

Angewandte Chemie, EarlyView.
Communicative nanomotors respond to elevated ROS in the tumor microenvironment, enabling active communication and selective mitochondrial targeting through non‐covalent surface engineering. Their precise interaction with cells induces mitochondrial damage, cytochrome c release, and pyroptotic cell death, while chemotactic motility ensures deeper tumor ...
Mingchen Sun, Luc van Oss, Chenxuan Wan, Daniela A. Wilson   +3 more
wiley   +2 more sources

Intraoperative Identification of Parathyroid Tissue Using the Ratio of Aspartate Transaminase to Lactate Dehydrogenase. [PDF]

Indian J Endocrinol Metab
Bhat G, Sooraj R, Mishra AK, Ramakant P, Rahalkar A, Rana C, Ali W, Singh KR.   +7 more
europepmc   +1 more source

Identification of ferroptosis‐related genes involved in chronic obstructive pulmonary disease based on bioinformatics analysis

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Green part represents the bioinformatics analysis approach. Yellow part represents the ideas of animal experiment. Abstract Background Chronic obstructive pulmonary disease (COPD) is a type of chronic respiratory disease.
Xuejing Luan, Jinghui Xie, Lu Zhang, Xiao Ma, Lichangtian Jiao, Jie Zhu   +5 more
wiley   +1 more source

Lactate Dehydrogenase A Crotonylation and Mono-Ubiquitination Maintains Vascular Smooth Muscle Cell Growth and Migration and Promotes Neointima Hyperplasia. [PDF]

J Am Heart Assoc
Chen ZH, Cao SH, Ren ZY, Zhang T, Jiang HM, Hu ZK, Dong LH.   +6 more
europepmc   +1 more source

Prognostic value of lactate dehydrogenase to albumin ratio in first-line chemoimmunotherapy for locally advanced or metastatic non-small cell lung cancer. [PDF]

Transl Cancer Res
Wei B, Cui H, Qian K, Shi K, Zhang P, Zhang Y.   +5 more
europepmc   +1 more source

Macrophage-Specific Lactate Dehydrogenase Expression Modulates Inflammatory Function In Vitro. [PDF]

Kidney360
Lu Y, Osis G, Zmijewska AA, Traylor A, Thukral S, Wilson L, Barnes S, George JF, Agarwal A.   +8 more
europepmc   +1 more source