Results 201 to 210 of about 930,544 (280)
Advanced Science, EarlyView.A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao +12 more
wiley +1 more source
Validation of a novel wearable, wireless technology to estimate oxygen levels and lactate threshold power in the exercising muscle. [PDF]
Physiol Rep, 2018 Farzam P +2 more
europepmc +1 more source
Advanced Science, EarlyView.Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu +15 more
wiley +1 more source
Association between different Non-Invasively Derived Thresholds with Lactate Threshold during graded incremental exercise. [PDF]
Int J Exerc Sci, 2018 Raleigh C, Donne B, Fleming N.
europepmc +1 more source
A Generative AI Framework to Predict Cardiomyocyte Contraction Function From Single Static Images
Advanced Intelligent Discovery, EarlyView.A single static hiPSC‐cardiomyocyte image is fed into a U‐Net‐GAN framework, which directly predicts a pixel‐resolved contraction heatmap without time‐lapse imaging. StyleGAN2‐generated synthetic cell–heatmap pairs augment training, improving prediction fidelity (SSIM = 0.84).
Andrew Kowalczewski +5 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.A hybrid Reinforcement Learning–Explainable AI framework integrates SHAP and LIME explanations directly into a Deep Q‐Network inference loop for real‐time ICU decision support. Trained on 18 142 mechanically ventilated stays from the eICU database, the system attains 93.0% decision accuracy, 20% fewer errors than RL alone, and a 91% clinician trust ...
Jannatul Ferdaus Disha +2 more
wiley +1 more source
Advances of the reverse lactate threshold test: Non-invasive proposal based on heart rate and effect of previous cycling experience. [PDF]
PLoS One, 2018 Messias LHD +2 more
europepmc +1 more source
Fatigue‐Driven Adaptive Assistance for a Semi‐Active Upper‐Limb Occupational Exoskeleton
Advanced Intelligent Systems, EarlyView.Physical fatigue during a physical activity is estimated in real time to enable adaptive exoskeleton assistance. By continuously adjusting the level of support according to the user’s fatigue, this approach reduces physical demand and provides a pathway toward personalized exoskeleton assistance.
Seemab Zakir +6 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.This review highlights recent advances in automated iPSC culture systems integrating robotics, advanced imaging, artificial intelligence, and process control. These technologies improve reproducibility, scalability, and quality in cell expansion, differentiation, and real‐time monitoring, while emerging AI‐enabled and closed‐loop approaches offer new ...
Hyoryong Lee +3 more
wiley +1 more source
Accounting for animal health in efficiency analysis: An application to Swedish dairy farms
American Journal of Agricultural Economics, EarlyView.Abstract Poor animal health is a central concern in modern livestock production. Despite the necessity to incorporate animal health in efficiency analysis, the theoretical and empirical developments are limited on this subject. This article appropriately characterizes the axiomatic properties of animal health within a production framework.
Frederic Ang +3 more
wiley +1 more source