Results 181 to 190 of about 39,607 (289)

Mechanistic Pathways of Gestational Obesity: Implications for Maternal and Offspring Health: A Narrative Review. [PDF]

Nutrients
Jahan-Mihan A, Leftwich J, Labyak C, Snyder J, Berg K, Nodarse RR.   +5 more
europepmc   +1 more source

Inferring causal relationships between reproductive and metabolic health disorders and production traits in first-lactation US Holsteins using recursive models [PDF]

, 2015
K. Dhakal, Francesco Tiezzi, J. Clay, Christian Maltecca   +3 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Clinical Benefits and Safety of Multiple Micronutrient Supplementation During Preconception, Pregnancy, and Lactation: A Review. [PDF]

Nutr Rev
Liu J, Mantantzis K, Kaufmann L, Campos Goenaga Z, Gromova O, Kuroda K, Qi H, Tetruashvili N, Di Renzo GC.   +8 more
europepmc   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Endocrine Disrupting Chemicals in Human Milk: A Systematic Review of Concentrations and Potential Health Implications. [PDF]

Curr Environ Health Rep
Dunn F, Sullivan H, Romano M, Chambers CD, Braun JM, Manz KE.   +5 more
europepmc   +1 more source

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

State-of-the-art treatment of postpartum bipolar disorder. [PDF]

Curr Opin Psychiatry
Kurimay T, Pelikán A, Tory V.
europepmc   +1 more source

Ingestion of low or high concentrations of ethanol during gestation and lactation: effects on postnatal development of offspring and evaluation of susceptibility to mental disorders in adulthood

Thalma Ariani [UNIFESP] Freitas
openalex   +1 more source